CA1

Question 1

Sinoatrial node

Answer 1

Accelerates

Beta 1 and beta 2

Question 2

GI walls

Answer 2

Relaxes

Beta 2 and alpha 2

Question 3

Ectopic pacemakers

Answer 3

Accelerates

Beta 1 and beta 2

Question 4

Contractility

Answer 4

Increases

Beta 1 and beta 2

Question 5

Skin, splanchnic vessels

Answer 5

Contracts

Alpha

Question 6

Skeletal muscles

Answer 6

Both contracts and relaxes

Relaxes : beta 2
Contracts : alpha

Question 7

Bronchiolar smooth muscle

Answer 7

Relaxes

Beta 2

Question 8

Sphincters

Answer 8

Contracts

Alpha 1

Question 9

Secretion

Answer 9

Inhibits

Alpha 2

Question 10

Cholinergic is generally associated to

Answer 10

Parasympathetic

Question 11

Examples of cholinergic receptors are

Answer 11

Nicotinic and muscarinic

Question 12

What does the parasympathetic control

Answer 12

Rest and digest

Question 13

What is the endogenous ligand for cholinergic receptors

Answer 13

Acetylcholine

Question 14

What is the endogenous ligand for sympathetic

Answer 14

Epinephrine or norepinephrine

Question 15

How many alpha receptor antagonist are there

Answer 15

3

Question 16

What are the alpha antagonists

Answer 16

Alpha 1 Selective , alpha 2 selective , non selective,

Question 17

How many beta receptor antagonists are there

Answer 17

4

Question 18

What are the beta antagonists

Answer 18

Non selective (1st gen), beta 1 selective (2nd gen), beta 1 selective (3rd gen), non selective (3rd gen)

Question 19

How many types of adrenergic agonists are there

Answer 19

3

Question 20

What are the types of adrenergic agonists

Answer 20

Indirect acting
Direct acting
Mixed acting

Question 21

What are the 4 types of indirect acting agonists for adrenergic receptors

Answer 21

MAO (monoamine oxidase)
COMT ( catechol O methyltransferease)
Releasing agents
Uptake inhibitor

Question 22

Is alpha 1 inhibotry or excitatory

Answer 22

Excitatory

Question 23

Is alpha 2 excitatory or inhibitory

Answer 23

Inhibitory

Question 24

Is beta 1 excitatory or inhibitory

Answer 24

Excitatory

Question 25

Is beta 2 excitatory or inhibitory

Answer 25

Inhibitory

Question 26

What is the affinity for beta 2 like

Answer 26

Affinity for only epinephrine

Question 27

What is the gene affected by polymorphism for PD

Answer 27

HLA-B*1502 (adverse rxns)
VKORC1 and HER2 (therapeutic effect)

Question 28

What is the gene affected by polymorphism for PK

Answer 28

Phase 1 : CYP2C19, CYP2C9, CYP2D6 (drug metabolism)
phase 2 : UGT1A1 (drug metabolism)
OATP1B1 (transporters)

Question 29

What are the methods to increase cholinergic effect

Answer 29

1. Increase agonists
2. Reduce cholinesterase

Question 30

How many types of anti cholinergic drugs are there

Answer 30

3

Question 31

What are the 3 cholinergic antagonists

Answer 31

1. Cholinesterase regenerator
2. Anti muscarinic
3. Anti nicotinic

Question 32

What are the 2 types of anti muscarinic drugs

Answer 32

M1 selective and non selective

Question 33

What are the 2 types of anti nicotinic drugs

Answer 33

Neuromuscular and ganglion blockers

Question 34

What kind of protein are muscarinic receptors

Answer 34

GPCR

Question 35

What kind of proteins are nicotinic rceptors

Answer 35

Ion channels

Question 36

What type of proteins are adreneergic receptors

Answer 36

GPCR

Question 37

What happens to the heart during sympathetic and how

Answer 37

Increase heart rate and contraction force

Beta 1

Constriction of blood vessels

Alpha 1

Question 38

What happens to the lungs during sympathetic and how

Answer 38

Dilation of brionchioles

Beta 2

Question 39

What happens to the GI during sympathetic and how

Answer 39

Sphincter contract alpha 1

Decrease motility movement alpha 2 and beta 2

Inhibit dsecretion alpha 2