C Reacccc Reactive Protein Flashcards
C reactive protein Members of the family known as
Pentraxin
It Increases rapidly within hours ? Following infection, surgery, or other trauma to the body.
4- 6 hours
Reaches peak value within
48 hours
Main substrate
Phosphocoline
Substances that will bind the foreign microorganism to make more than more susceptible to phagocytosis
Opsonin
Produced by the
Liver under the control of?
IL-6
Serum concentrations can increase? with an acute inflammatory reaction.
1000 fold
CRB binds to specific receptors found on
Monocytes, macrophages , neutrophils
True or false?
Cop acts some what like an antibody as it is capable of opsonization, agglutination, precipitation and activation of complement by the classical pathway.
True
Normal level ranges from?
0.1mg|dl in newborns
0.5 mg/ dl in adults
True or false?
C-reactive protein rapid latex agglutination test is based on n the reaction between patient seem containing CPR as an antigen and the corresponding anti CRP antibody coated to the treated surface of latex particles.
True
True or False
Coated particles enhances the detection of an
Aggluti nation reaction when an antigen is present in the serum being tested.
True
Reagent of cop determination
1 percent suspension of polystyrene latex particles coated with anti - human CRP produced in goats or rabbits.
Reasons for false- positive reaction
Head reaction time longer than 2 minutes
Specimen are lipemic hemolyses
Contaminated with bacteria
Because the latex slide agglutination test is qualitative I semiquantifatile procedure other method as such as nephelometry should be used for determination of quantitative determination of the CRP level when indicated.
True
