Adaptive Immunity -3 Flashcards
B cell progenitors’: contact with bone morrow
Pro B cells
Il-7 necessary at this early developmental stage.
Pro B cells
Rearrangement of genes
Pro B cells
Markers that include surface antigens
CD19
CD45
CD43
CD24
C-kit
Tdt
Rag -1
Rag -2
Chromosome involve in rearrangement of genes
Chromosome 14
Cd that is always present in every phase
CD19
1st heavy chain synthesized al the new chains
Igm- immunoglobulin
Pre B sells
2 heavy chains and surrogate light chain
Pre B cell
Elimination of B cells that become self reactive receptors
Immature B cells
Major histo compatibility complex MHC
class ii molecules
CD21, 40
What Cd is important in the interaction of 3 cells within T cells
Cd 40
Receptor for breakdown product of component C3.
CD21
Remain in the spleen
Marginal B cells
Migrate to lymph nodes
Follicular B cells
Proteins on the surface of mature B cells
Cd 19
cd 21
Cd 81
Cd 225
Cd 19 complex
Presence of CD25 and IL -2
Activated B cells
Transform into a blast will give rise to both plasma cell and memory cell
Activated B cell
Antibody production
Plasma cells
Spherical or ellipsoial cells between 10 and 20 nm
Little no surface immunoglobulin
Plasma cells
Located in germinal centers in the peripheral lymphoid organ
Plasma cells
T or F
in bone marrow, plasma cells can curare in niches around by stromal cells
True
T or F
Plasma cells, found elsewhere are non dwiding and after several days of antibody production they die without proliferation
TRUE
Responsible for the memory for the adaptive immunity
Memory cells
Cell to cell contact
T-lymphocytes
Responsible for cellular immune responses and are involved in the regulation of antibody reactions in conjunction with B lymphocytes
T lymphocytes
Early surface markers
Tells include CD44 and CD25
