Ad-4 Flashcards
Is an elaborate process that takes place over 3 week period as cells hilts through the cortex to medulla.
Maturation
Critical for growth differentiation
Il-7
Early thymocytes lack?
CD4 and CD8
Produce interferon gamma IFN-y
Interlukin IL-2
TFn-B
TH1 cells
Activating cytotoxic lymphocytes and macrophages
TH1 cells
Including IL-4 , IL- 5, 6, 7,9,10,13
TH2 cells
Help B cells produce antibodies against extacellular pathogens
TH2 cells
CDC 4 and CD 25
T regulatory (treg cells)
Suppressing the immune response to self antigens
T regulatory
Inhibit proliferation of otherT cell populations
T regulatory
Produce IL-9 , proinflammatory effect
Th9 cells
Epithelial surfaces by wording off fungi
Th9 cells
IL 17 and IL 22
Th 17 cells
Increase inflammation and joint destruction
TH17 cells
Associated with rheumatoid arthritis, multiple sclerosis and inflammatory bowel
Th17
Larger than B cells of T cells. 15 diameter.
Natural killer cells
Kidney shaped nuclei with condensed chromatin and prominent nuclei
Nk cells
Mediate cytolytic reactions kill target cells
NK cells ‘
CD16
56
94
Nk cells
Lak cells in response to IL-2
Nk cells
Important cellular defense part of innate immunity
Nk cells
First line of defense against cells that are virally infected
Nk cells
Recognize and damage cell to eliminate such target cells without prior exposure to them.
Nk cells
Lack specificity
Nk cells
Balance between activating and inhibitory signals
Mechanism of cytotoxity
Deliver inhibitory signals
Killing of cells
Inhibitory receptors
Deliver signals to activate cytotoxic mechanism
Activators receptors
CD94
NKG2C and CD94
NKG2D on NK cells
Bind mica or micb and send signal to destroy the cell.
KIRS
Killer cell immunoglobulin like receptors
