C diff Flashcards

1
Q

Characteristics of BI/NAP1/027

A
high level fluoroquinolone resistance
efficient sporulation
high toxin production
death 3 x normal
more likely to fail treatment with metro
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2
Q

WCC in C diff

A

up

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3
Q

ELISA detects

DNA based tests ID

A

toxins
toxin genes

PCR for toxin is most sens and spec

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4
Q

hypervirulent strain mech

A

deleted tcdC gene which normally represses toxins A and B production

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5
Q

wash hands with

A

soap and water- spores

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6
Q

second relapse

A

fidaxomicin (does not work in NAP1 strains)

or

tapered and pulsed vanc

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7
Q

treatment

A

mild to mod- metro
severe- oral vanc

if very severe add IV metro to oral vanc

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