C diff Flashcards
1
Q
Characteristics of BI/NAP1/027
A
high level fluoroquinolone resistance efficient sporulation high toxin production death 3 x normal more likely to fail treatment with metro
2
Q
WCC in C diff
A
up
3
Q
ELISA detects
DNA based tests ID
A
toxins
toxin genes
PCR for toxin is most sens and spec
4
Q
hypervirulent strain mech
A
deleted tcdC gene which normally represses toxins A and B production
5
Q
wash hands with
A
soap and water- spores
6
Q
second relapse
A
fidaxomicin (does not work in NAP1 strains)
or
tapered and pulsed vanc
7
Q
treatment
A
mild to mod- metro
severe- oral vanc
if very severe add IV metro to oral vanc