butyrophenones and phenothiazines Flashcards

1
Q

example of phenothiazines

A

acepromazine

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2
Q

example of butyrophenones

A

azaperone

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3
Q

antipsychotics are antagonists of which type of receptor

A

D2 (dopamine)

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4
Q

dopamine receptors are what type of receptors

A

heptahelical G-protein coupled receptors

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5
Q

what are the non-dopaminergic effects

A

autonomic nervous system

  • antiadrenergic (a1 and a2 receptors) (hypotension)
  • increased affinity for a1 and a2 receptors more than dopamine receptors
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6
Q

absorption of acepromazine

A
  • relatively slow after IM administration (15-30min)
  • poor oral bioavailability (~20% but variable)
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7
Q

distribution of acepromazine

A
  • highly lipophilic, highly membrane or protein bound - widely distributed
  • accumulate in brain, lung or other VRG tissues
  • enter fetal circulation and breast milk
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8
Q

acepromazine CNS

MAC

A

mac reduction - 30-40% (decreases inhalent amount)

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9
Q

acepromazine: hematologic system

A
  • Hct decreased by 20-50% in dogs and horses
  • due to splenic sequestration
  • occurs within 30 min and persists for 2 hrs
  • mag and duration of effect is dose dependent
  • platelet aggregation is also inhibited - minimal hemostatic significance
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10
Q

acepromazine: integumentary system

A

antihistaminergic effects - not suitable for use in allergic skin testing patients

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