butyrophenones and phenothiazines Flashcards
1
Q
example of phenothiazines
A
acepromazine
2
Q
example of butyrophenones
A
azaperone
3
Q
antipsychotics are antagonists of which type of receptor
A
D2 (dopamine)
4
Q
dopamine receptors are what type of receptors
A
heptahelical G-protein coupled receptors
5
Q
what are the non-dopaminergic effects
A
autonomic nervous system
- antiadrenergic (a1 and a2 receptors) (hypotension)
- increased affinity for a1 and a2 receptors more than dopamine receptors
6
Q
absorption of acepromazine
A
- relatively slow after IM administration (15-30min)
- poor oral bioavailability (~20% but variable)
7
Q
distribution of acepromazine
A
- highly lipophilic, highly membrane or protein bound - widely distributed
- accumulate in brain, lung or other VRG tissues
- enter fetal circulation and breast milk
8
Q
acepromazine CNS
MAC
A
mac reduction - 30-40% (decreases inhalent amount)
9
Q
acepromazine: hematologic system
A
- Hct decreased by 20-50% in dogs and horses
- due to splenic sequestration
- occurs within 30 min and persists for 2 hrs
- mag and duration of effect is dose dependent
- platelet aggregation is also inhibited - minimal hemostatic significance
10
Q
acepromazine: integumentary system
A
antihistaminergic effects - not suitable for use in allergic skin testing patients