Building tissues from cells Flashcards

1
Q

What are tissues?

A

collections of similar cells and the material surrounding them

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2
Q

What is tissue classification based on?

A
  • structure of cells,
  • the composition of the extracellular matrix,
  • the functions of the cells in a particular tissue.
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3
Q

What are 4 major types of adult tissues?

A
  • Epithelial
  • Connective
  • Muscle
  • Nervous
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4
Q

What is structure of epithelia?

A
  • sheets of cells
    – v. close together,
  • flat/folded
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5
Q

What is main function of epithelia?

A
  • they cover the body surface (epidermis)

- they line almost all internal cavities

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6
Q

How do epithelia receive nutrients, oxygen and metabolites?

A
  • depend upon diffusion
  • blood vessels never pass through the basement membrane/sheets of epi cells
    – but blood vessels in connective tissue underneath basement mem – diffusion occurs
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7
Q

How is epithelia organised e.g in gut wall?

A
  • lumen
  • epithelial cells
  • basement membrane
  • CT
  • smooth muscle
  • CT
  • epi cells
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8
Q

What is the importance of the basement membrane?

A
  • phys barrier between epi cells + connective tissue cells + cells of blood supply
  • provide support and attachment between them
  • all cells except immune cells stay on 1 side/other of basement mem
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9
Q

What are 4 ways epi tissue classified?

A
  • cell shape
  • layer structure
  • surface specialisation
  • location & function
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10
Q

What are the 3 shapes of epi tissue?

A
  1. squamous
  2. cuboidal
  3. columnar
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11
Q

What is structure of squamous epi?

A
  • flattened
  • layer parallel to mem,
  • v.thin
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12
Q

What is structure of columnar epi?

A
  • sideways flattened sheet.

- Cells tall + thin

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13
Q

What are 3 layer structures of epi?

A
  • simple
  • pseudostratified
  • stratified
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14
Q

What is structure of simple epi?

A
  • 1 layer of epi sheets
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15
Q

What is structure of pseudostratified epi?

A
  • 2-3 layers of cells
    – every cell attached to BM (so should really be simple but looks stratified hence pseudostratified)
  • Tall + thin columnar cells.
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16
Q

What is structure of stratified epi and how does it originate?

A
  • multiple layers
  • only bottom cells touching BM.
  • Cells proliferate to produce daughter cells and move and build up to apical surface
17
Q

What are the 3 surface specialisations?

A
  • ciliated
  • microvilli
  • keratinised
18
Q

What is structure of cilia?

A
  • core of 20 microtubules arranged as

9 doublets around a central pair (“9+2”)

19
Q

What is function of cilia?

A

motile structures for moving fluid and particles along epithelia surface

20
Q

How does cilia originate?

A
  • microtubules grow out from a basal
    body
  • structurally identical to a centriole and acts as a template
21
Q

What is size of cilia?

A
  • 7-10 µm long
22
Q

Where is cilia found?

A

Lines much of upper respiratory tract and

trachea, bronchi and larger bronchioles