BugsAndDrugs

Question 1

Gram + cocci

Answer 1

Staphylococcus 

Streptococcus 

Enterococcus

Question 2

Gram – cocci

Answer 2

Neisseria gonorrhea

Question 3

Gram – bacilli

Answer 3

E. coli

Pseudomonas

Question 4

Gram + anaerobic bacilli

Answer 4

Clostridia

Question 5

Gram - anaerobic bacilli

Answer 5

Bacteroides

Question 6

Atypical

Answer 6

Chlamydia

Mycoplasma

Question 7

Which cell wall synthesis inhibitors are absorbed PO?

Answer 7

PCN -V 

Oxacillin , Dicloxacillin, 
Amoxicillin , Ampicillin 
___________________ 

All cephalosporins except 
- Cefazolin (1st)
, Cefoxitin (2nd) , Ceftriaxone (3rd)

____________________ 

Carbapenams 

____________________ 

Vanc except 
- when treating C.Diff

Question 8

Sulfonamides are absorbed PO or administered IV?

Answer 8

PO

Question 9

Drugs that distribute to CSF

Answer 9

PCN (if tissue is inflammed) , Ceftriaxone (3rd gen ceph), 
Carbapenams

___________ 

Chloramphenicol , Metronidazole , 
Sulfonamides

Question 10

Drugs that distribute to urine

Answer 10

AG, 
FQ 
- (Cip, Levo), 
NF

Question 11

Drugs that distribute to bone

Answer 11

Clindamycin 


Metrinidazole

Question 12

Drugs that distribute to lungs

Answer 12

Macrolides (ACE)


FQ 
- Levo, Mox

Question 13

Drugs that distribute to bone (Bad)

Answer 13

TCN

Question 14

Drugs that distribute to teeth (Bad)

Answer 14

TCN

Question 15

TCN

Answer 15

AGs

Question 16

Drugs that contribute to 8th nerve damage (bad)

Answer 16

AGs

Question 17

Drugs that distribute to fetus (Bad)

Answer 17

Cephalosporins, 
Macrolides, (ACE), 
TCN

______________ 

Sulfonamides

Question 18

Drugs that are eliminated Non-renally can cause what 3 negative side effects?

Answer 18

1. drug-drug interactions, 
2. genetic polymorphisms in metabolizing enzymes, ] 
3. potential for hepatotoxicity:

Question 19

List Drugs that are eliminated Non-renally

Answer 19

D - oxycyclin 

Q - uinolones (mox) 

C - lindamycin 

R - rifampin 

I - soniazid 

M - etronidazole
 
E - rythromycin like drugs (ery and Azi are biliary excretion) 

S - ulfonamides

Question 20

Which DQCRIME drugs are inhibitors of P450?

Answer 20

Quinolones 
Erythromycin

Question 21

Which DQCRIME drugs are inducers of P450?

Answer 21

Rifampin

Question 22

Metronidazole and Erythromycin like drugs are at risk for DDI, but via different mechanisms. Explain

Answer 22

Metronidazole: drug-drug interaction with alcohol due to inhibition of aldehyde metabolism (Antabuse reaction)

Erythromycin-like: drug-drug interactions due to inhibition of P450 (Clar-Ery not Azi)

Question 23

Renally excreted drugs

Answer 23

PCN 
Cephalosporins 

Carbapenams 

Vanc 

\_\_\_\_\_\_\_\_\_ 

AGs 

FQ (Cip, levo)

Question 24

-Cidal drugs

Answer 24

All the CW synth inhibitors 

\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ 

Oxazolidinones for strep 

Streptogamin (whn used synergistically w/ quinupristen) 

AGs
 
\_\_\_\_\_\_\_\_\_\_\_\_ 

All inhibitors of DNA fxn

Question 25

• Static drugs

Answer 25

Macrolides (ACE) , Clindamycin , 
Chloremphenicol , 
Oxazolidinones , 
TCN

• Basically All protein synthesis inhibitors except: 
Oxazolidinones for strep , 
Streptogamin (whn used synergistically w/ quinupristen) , 
AGs

Question 26

Which Protein synthesis inhibitors inhibit the 30s subunit?

Answer 26

TCN


AGs

Question 27

Narrow spectrum drugs list

Answer 27

PCN 

VANC

AGs

Question 28

Extended spectrum drug list

Answer 28

Extended spectrum PCN

Anti-pseudomonal (PIP/Tazo)

Cephalosporin 
Carbapenam

Question 29

Broad spectrum drug list

Answer 29

Macrolides
 
Chloramphenicol 

TCN 

FQ 

Sulfonamides