Antimicrobials Flashcards
Doxycycline
non-renally eliminated tetracycline
Quinolones
ciprofloxacin is renally eliminated but is a non-substrate inhibitor of P450 (caffeine-theophylline)
Clindamycin
non-renally eliminated
Rifampin
inducer of P450, potential for hepatotoxicity
Isoniazid
genetic polymorphism of N-acetyl transferase metabolism, potential for hepatotoxicity
Metronidazole
drug-drug interaction with alcohol due to inhibition of aldehyde metabolism (Antabuse reaction)
Erythromycin-like
drug-drug interactions due to inhibition of P450 (Clar-Ery not Azi)
Sulfonamides
N-acetylated to a more lipid-soluble metabolite → concern for renal crystalluria
Gram positive cocci
strep pneumo strep pyogenes strep viridans staph aureus (MSSA-MRSA) enterococcus faecium-fecalis
gram negative cocci
n. gonorrhea
gram positive rod
NONE
gram negative rod
e coli
h nfluenza
klebsiella
pseudomonas aeruginosa
anaerobe- gram positive rod
c diff
c perfringens
c botulinum
c tetani
anaerobe- gram negative rod
bacteroides fragilis
atypical
chlamydia
mycoplasma pneumoniae
strep pneumo
pneumonia
otitis media
sinusitis
strep pyogenes
pharyngitis
strep viridans
endocarditis
staph aureus
cutaneous infection
pneumonia
bacteremia
device assoc infections
enteroccocus faecium-fecalis
bacteremia
intraabdominal infection
UTI
gonorrhea
gonorrhea
e coli
UTI intraabdominal infection lower respiratory infection bacteremia traveler's diarrhea
h influenza
meningitis
otitis media
sinusitis
community acquired pneumonia
klebsiella
UTI
intraabdominal infection
lower respiratory infection
bacteremia
pseudimonas aeruginosa
nosocomial infections (UTI/pneumonia)
c diff
pseudomembranous colitis
bacteroides fragilis
intraabdominal
brain abscess
chlamydia
trachoma
community acquired pneumonia
urethritis
mycoplasma pneumonia
community acquired pneumonia
Drugs-Drug Classes eliminated by renal excretion requiring dosage adjustments if renal impairment
Penicillins - Cephalosporins- Vancomycin- Aminoglycosides- Fluoroquinolones
