Bugs & drugs (Antifungals)

Question 1

Amphotericin B treats?

Answer 1

Systemic mycoses: Cryptococcus, Blastomyces, Coccidioides, Histoplasma, Candida, Mucor

Question 2

Nystatin treats?

Answer 2

Candidiasis, but it is topical only! “Swish and swallow” for oral thrush, topical for diaper rash and vaginal candidiasis

Question 3

The azoles treat?

Answer 3

Local and less serious mycoses.

• Fluconazole for chronic suppression of cryptococcal meningitis in AIDS and candida infections of all types
• Itraconazole for Blastomyces, Coccidioides, Histoplasma
• Clotrimazole & Meconazole for topical fungal infecions

Question 4

Flucytosine treats?

Answer 4

Systemic fungal infections; used in combo with Amphotericin B (esp. cryptococcal meningitis)

Question 5

Caspofungin, Micafungin treats?

Answer 5

Invasive aspergillosis, Candida

Question 6

Terbinafine treats?

Answer 6

Dermatophytoses (especially finger or toe nail infections)

Question 7

Griseofulvin treats?

Answer 7

Tinea, ringworm