Bridget Penman

Question 1

Rather than saying in vivo

Answer 1

say in the […] model

Question 2

epitope

Answer 2

is just where the Ab binds, not necessarily neutralising

Question 3

Mouse model advantages

Answer 3

• highly tractable
• well understood
• easy to work with
• can be reared in high numbers, cheaply

Question 4

Mouse model limitations

Answer 4

• different immunities
• inbred
• different pharmacokinetics and pharmacodynamics
• different optimal dosage

Question 5

sample sizes in mice

Answer 5

• ethical considerations
• balancing this with statistical power