Breast Ultrasound Flashcards
What are the risk factors for breast ultrasound? 3 (what increases it?)
- Lifestyle
- Hereditary factors
- Reproductive/ hormonal factors
What are some examples of lifestyle behaviours for breast ultrasound? 3
- Obesity
- Physical inactivity
- Alcohol intake
What are some reproductive/ hormonal factors for breast ultrasound? 5
- Older age at first brith
- Late menopause
- Menstruation at an early age
- BCP
- HRT
What are some indication for breast ultrasound? 10
- Complements mammography
- Identify and characterize an abnormality
- Dense breast tissue
- Equivocal mammogram or physical findings
- <30 years of age: initial
- Pregnant/ lactating breast
- Male breast
- Interventional guidance
- Breast implants
- Treatment planning for radiation therapy
What are some advantages for ultrasound for breast ultrasound? 6
- Non invasive
- Painless
- Non-ionizing
- Low cost
- Image chest wall
- Doppler
What is the anatomy of the mammary gland? 3
- Modified sweat gland
- Fat, glandular and fibrous tissue
- Three layers
What are the three layers of the mammary gland?
- Subcutaneous
- Mammary
- Retromammary
Label the image
Label the image
Where is the subcutaneous (premammary) area located?
Between skin and mammary fascia
What is the subcutaneous area?
Fat surrounded by connective tissue
Does the subcutaneous area have breast lesions?
No
What is the mammary fascia?
Connective tissue enveloping mammary zone
What is the mammary fascia continuous with?
Coopers ligaments
What supports and shape Breast?
Cooper’s ligaments
Which of the three layers is the functional layer?
Mammary layer
Which of the three layers is a fibroglandular tissue?
Mammary layer
Where is the mammary layer located?
UOQ and areolar region
How many lobes are in the mammary layer?
15-20 lobes
How is the 15-20 lobes in the mammary layer look like?
Variable
How is the 15-20 lobes of the mammary layer arranged?
Radially
What are the 15-20 lobules consistent of? 3 (What are they composed of)
- Ducts
- Stroma
- Acinus
How many lobules are located in the mammary layer?
20-40 lobules per lobe
Where are the acini located?
In the lobules
What are the acini?
Milk producing glands
What does the ducts (lactiferous) in the mammary layer drain (what ducts)
Drain acini, lobules, lobes
What does the ducts (lactiferous) of the mammary layer converge towards?
Nipples > Lactiferous sinus
What is the TDLU?
Functional unit of the mammary layer
What does the TDLU consist of ?
Lobule and extralobular terminal duct
How big is the TDLU?
1-2 mm
What is the site of most major breast pathology?
TDLU
Label the image
What is the tail of Spence?
Mammary tissue extending into the axilla region
Label the image
What is the retromammary layer?
Deepest layer, thin
What does the retromammary layer consist of? 3
- Fat
- Blood vessel
- Lymphatics
What is the nipple?
Fibromuscular papilla projecting form the center of the breast
What is a inverted nipple?
Normal variant
How many openings are in nipples?
Multiple openings
What is the areolas?
Pigmented area around the nipple with sebaceous glands (bumpy appearance)
What is the pectoral is major located in relation to th retromammary layers?
Posterior to retromammary
What is the pectoralis minor covered by?
Pec major
What is the vascular supply for the breast? 3
- Lateral thoracic
- Internal mammary
- Intercostal arteries
What does the Venous drainage of the breast consist of? (For lymph)
Deep and superficial network
What is the lymph flow of the breast? (Where it flows to?)
Flows to axilla
Where does the lymph supply in the breast originate?
In the connective tissue of lactiferous ducts
What has frequent invasion with Br.Ca?
Lymph nodes
What is the primary function of breasts?
Produce and secrete milk
Age and stage of breast function influence what?
The amount of parenchyma and stroma
What hormones are found in the breast? 4
- Estrogen
- Progesterone
- Prolactin
- Oxytocin
What does progesterone do in the breasts?
Stimulates development of lobular cells
What does prolactin do in the breast?
Stimulates milk production
What does oxytocin do in the breast?
Causes milk ejection from lactating breast
What does estrogen do in the breast?
Promotes growth of ductal tissue
What is the physiology of prepubescent breasts?
- Rudimentary ducts
- Tissue developing under nipple, little fat
What is the physiology of the young adult? 2
- Fibroglandular tissue (Dense)
- Minimal fat
What is the physiology of the adult?
Fibroglandular = fat
What is the physiology of the pregnant/ lactating breast?
Mostly glandular/ prominent ducts
What is the physiology of the older breast?
Increase fat
What is the physiology of the menopause breast?
Parenchyma beneath nipple and UOQ
What is the physiology of the postmenopause breast?
Fatty tissue
What can ultrasound identify in the breast? 10
- Skin
- Nipple
- Subcutaneous fat
- Parenchyma
- Lactiferous ducts
- Cooper’s ligaments
- Retromammary layer
- Muscles
- Ribs
- Nodes
What is the sonographic appearance of the skin?
- 2 thin echogenic lines
- 2-3 mm
What is the sonographic appearance of the nipple? Does it shadow?
- Homogenous medium level
- Posterior shadowing
What is the sonographic appearance of the subcutaneous fat? Does it extend past the nipple? How much does one have?
- Amount varies
- Does not extend posterior to nipple
- Hypoechoic, thin echogenic strands, edge artifact
What is the sonographic appearance of the parenchyma? 3 (compared to fat, what of the interspersed fat, ducts)
- Homogenous, echogenic compared to fat
- Interspersed hypoechoic zones (Fat)
- Ducts - hypoechoic/ anechoic tubular structure
What is the sonographic appearance of the cooper ligaments?
Curved echogenic striations encasing hypoechoic fat lobules
What is the sonographic appearance of the retromammary layer?
Hypoechoic due to fat, anterior to muscle
What is the sonographic appearance of the pectoralis muscle?
Medium to low level echoes, striated
What is the sonographic appearance of the ribs? 2 (lateral, medial cartilage)
- Lateral ribs - acoustic shadowing
- Medial cartilage - hypoechoic
Where are the nodes located? How big are they? What is the sonographic appearance of the nodes?
- In axilla and parenchyma
- <1cm
- Oval, hypoechoic, echogenic hilum
What transducer should we use for breast ultrasound?
Highest frequency tranducer
How should position the patient? 3
- Supine or slightly obliqued
- Prop patient with cushion of foam wedge
- Ipsilateral arm placed above head
How much pressure should we use for breast exams? How should we adjust pressure?
- Moderate pressure
- Adjust to penetrate to breast wall
How many planes should we scan the breast?
2 planes
How should we measure lesions in the breast?
- In two orthogonal planes
- Sagittal and transverse
- Radial/ anti radial
What does this image demonstrate?
- Quadrant and clock-face annotation
- Transducer scan planes
What doe we scan the axilla for?
Nodes
When scanning the nipple, what do we do? How do we angle?
- Place probe adjacent to the nipple
- Angle retroareolar
How should we label the breast exams? 4
- Right or left
- Quadrants
- O’clock
- Plane (sag/ trans, rad/ ARad)
Label the quadrants
What BIRADS stand for?
Breast imaging reporting and data system
What is BIRADS
- A standardized form of reporting and documenting breast lesions
- Risk categorization
What does BIRADS classifies?
Lesions according to suspicion of breast cancer
What are the different levels of BIRADS?
What are some abnormalities in the breast exams? 4
- Benign
- Malignant
- Augmented Breast
- Gynecomastia
Which demographic of individuals are affected by breast cyst?
35-50
How are cysts common formed in the breasts
Obstructed ducts
How does cysts feel like?
Palpable and round
How many cysts are commonly seen?
Single/ multiple
What is the size of cysts?
Variable size that can change with compression
What does this image demonstrate?
Simple cyst in a mammogram and a ultrasound
What does complex cysts look like sonographically? 3
- Low level echoe s
- Septations
- Posterior enhancement
What are acorn cyst? (how they look?)
Cysts that display a non-dependent echogenic layer
What is the most common benign solid tumor in the breast?
FIbroadeomas
When does fibroadenomas form?
In adolescence
What is fibroadenomas stimulated from? What can make them grow
Estrogen and may increase in size with pregnancy and HRT
What is the size and shape of fibroadenomas? 2
- Variable size
- Variable shape
Are fibroadenomas unilateral or bilateral? And how do they feel?
- Unilateral/ bilateral
- Palpable, painless and mobile
What does this image demonstrate?
Fibroadenomas. Notice the
What is cystosarcoma phylloides referred to?
Giant fibroadenoma
How common is cystosarcoma phylloides?
Rare
Is Cystosarcoma phylloides benign or malignant?
Typically benign but malignant transformation possible
Which demographic of individuals are affected by cystosarcoma phylloides?
Individuals that are 40-50 years
What is cystosarcoma phylloides similar to?
Fibroadenomas except it is larger and more Lobulated
Which pathology rapidly increases in size?
Cystosarcoma phylloides
What is this an example of?
Cystosarcoma Phylloides
What are lipomas?
Asymptomatic benign fatty tumor
Which demographic of individuals are affected by lipoma?
Middle aged/ postmenopausal patient
Lipomas can be what type of mass? (what does it look like)
Hypoechoic mass
What are defined as margins?
Lipomas
What is this an image of?
Lipoma
What is fat necrosis?
Hemorrhage or liquefaction of fatty area
What does fat necrosis lead to?
Leads to necrosis
What causes fat necrosis? 3
- Trauma
- Surgery
- Inflammation
Fat necrosis forms what?
Dense scar or cysts (lipid cysts)
The fat necrosis area may do what eventually?
Calcify
How might a fat necrosis feel? 3
- Firm nodule
- Skin retraction
- Nipple inversion
How might a fat necrosis look like? 3
- Irregular hpoechoic
- Complex mass
- May shadow
What does this image demonstrate?
Fat necrosis
What is a papilloma?
- Benign solid masses in lining of ducts, can also develop in a cyst
What is the most common cause of blood nipple discharge?
Papilloma
Where is a papilloma located?
Near nipple
What kind of lesion is a papilloma?
Solid lesion in a duct or cyst
Papillomas are possible_______ near mass
Ductal ectasia
What are vascular stalks?
Papillomas
What does the arrows point to?
Papilloma
How common are fibrocycstic change?
Common
How do fibrocystic cyclic changes present like in breast tissue?
Exaggerated cyclic changes in breast tissue
What does the cells in fibrocystic changes do?
Cells proliferate and retain water
Which quadrant are fibrocystic changes located?
Typically UOQ
What does fibrocystic changes look like sonographically? 3
- Multiple cysts
- Echogenic tissue
- Small nodules
What are some sign and symptoms of fibrocystic changes? 3
- Lymph, swollen, painful breasts, modularity
- Nipple discharge
- Mammographies changes
What are galactocele? Where are they located in relation to the areola?
- Obstructed lactiferous duct
- Retroareolar
What does Galactocele often lead to?
Mastitis
H what does galactocele look like on U/S? 3
- Well-defined cystic mass
- Less posterior enhancement
- Internal debris
What does this image demonstrate?
Galactocele
What is duct ectasia?
Asymptomatic tubular hypoechoic structure converging toward nipple (>8mm)
Who does duct ectasia usually affect?
Lactating patients and >50 years of age
What can duct ectasia lead to?
Mastitis
What is mastitis?
Breast inflammation (focal or diffuse)
When is mastitis common?
During lactation
Why is mastitis bad?
Obstruction leads to bacterial infection
What can develop due to mastitis?
Abscess?
What are some signs and symptoms of Mastitis? 3
- Hot, red, tender breast, fever
- Palpable mass
- Nipple discharge
What does acute inflammation/ infections look like in breast tissue? 5
- Irregular fluid collection with debris
- Loss of tissue definition (edematous)
- Complex collection/ shaggy wall
- Septations
- Posterior enhancement
What does this image demonstrate?
Acute inflammation/ infection
What does nipple discharge include in terms of ethologies?
Both low and high risk ethologies
What are some low risk nipple discharge ethologies? 3
- Bilateral, multiple duct orifices
- Milk or greenish
- Fibrocystic change or duct ectasia
What are high risk nipple discharge? What is needed to analyze?
- Unilateral, spontaneous, clear, bloody, serous
- Galactogram procedure
What do we assess for breast malignancies?
Assess breasts lesions for malignant characteristics
What are some malignant lesions categorizations? 2
- Location
- Invasiveness
Where are locations of malignant lesions? 2 (location as in tissue)
- Ductal
- Lobular
What are malignancies invasiveness? 2
- Non-invasive (in-situ)
- Invasive (infiltrative)
What are the assessment criteria for breast exams? 8
- Shape, size, number
- Orientation
- Location (UOQ common)
- Margins
- Echogenicity/ Echotexture
- Internal echo content (cystic/ solid)
- Shadowing or enhancement
- Effect on surrounding tissue
What are some malignant characteristics? 9
- Hypoechoic
- Taller than wide
- Angled margins/ speculations
- Heterogenous
- Posterior shadowing
- Thick echogenic rim or halo
- Ductal extension
- Micorlobulations
- Calcifications
What are some malignant characteristics? 9
- Hypoechoic
- Taller than wide
- Angled margins/ speculations
- Heterogenous
- Posterior shadowing
- Thick echogenic rim or halo
- Ductal extension
- Micorlobulations
- Calcifications
What are some secondary findings examples? 6
- Skin changes
- Inverted nipple
- Axillary or intramammary lymph nodes
- Dilated ducts
- Highly echogenic surrounding tissue
- Thickened Cooper’s ligaments
What are some types of non invasive carcinomas? 2
- DCIS
- Lobular carcinoma in Situ
What does DCIS stand for?
Ductal carcinoma in Situ
What are examples of infiltrating (invasive) Carcinomas? 3
- Infiltrating ductal
- Infiltrating lobular
- Intracystic papillary carcinoma in Situ
Where does ductal carcinoma in Situ arise from?
Ducts
What is the most common noninvasive tumor?
DCIS
When does DCIS typically arise?
Postmenopausal
What does DCIS usually present with? 2
- Microcalcifications in 80%
- Nipple discharge
Which non-invasive carcinoma is not a cancer?
Lobular carcinoma in Situ
When does lobular carcinoma in Situ have a increased incidence?
In reproductive years
How common is intracystic papilllary carcinoma in Situ?
Rare
Which demographic is usually afflicted with Intracystic papillary carcinoma in Situ?
Middle age females
What does intracystic papillary carcinomas in Situ look like sonographically?
Well defined, mobile mass
What is the most common type of invasive carcinoma?
Invasive ductal carcinoma
What does invasive ductal carcinomas present like? 4
- Hard
- Stationary
- Painless
- Palpable mass
Where is Invasive ductal carcinomas located commonly? (quadrant)
UOQ
What does Invasive ductal carcinomas present with? 2
- Microcalcifications
- Spiculations
How often is the incidence rate of invasive lobular carcinomas?
8-13%
What is the most frequently missed cancer?
Invasive lobular carcinoma
Invasive lobular carcinoma development is commonly where?
Secondary primary in opposite breast
What does the nipples look like with invasive lobular carcinoma?
Nipple retraction
Is it hard to detect invasive lobular carcinoma?
Difficult to detect with mammogram and clinically
What invasive tumor is rare, fast growing, affects middle aged women, and looks like a fibroadenoma?
Medullary
What is a mutinous tumor? How common is it? Who does it affect? 3
- Rare
- Slow growing invasive tumor
- Affects older women
What are papillary tumours? Who’s does it affect? 2
- Invasive tumours
- Postmenopausal women
What is a common sign for papillary tumours?
Blood nipple discharge
Where is papillary tumours located? (area)
Central breast area
What is the prognosis like for papillary muscles?
Good
What are augmented/ implanted breasts made of?
Saline or silicone
Where are implants placed?
Placed anterior or posterior to pectoralis muscle
How easy is it to evaluate augmented breasts with mammography?
Difficult
If mammography has a hard time doing breast exams on implants what should we do?
Use ultrasound
What are come concerns with Implants? 3
- Contracture
- Obscures normal breast tissue on mammo
- Leakage or rupture
What does implants look like sonographically? 2
- Relative echo free oval posterior to breast tissue
- Anterior reverberation Normal
Label the image
What are things we see in the normal implant? 2
- Radial folds
- Fill valves
Radial folds are dependent on what?
Anterior folds and patient position
When/ would we see fill valves? 2
- With saline implants
- Posterior to nipple typically
How do fill valves feel?
Palpable
What are two types of leakages with silicone implants? 2
- Intra-capsular
- Extra capsular
What does intravascular leaks look like? 3
- Tear in shell
- Gel between the capsule and shell
- Step ladder sign
What is this an example of?
Intracapsular rupture
What is this an example of?
Extracapsular rupture
What does extra-capsular leaks look like?2
- Tear through the shell and capsule
- Snowstorm appearance
Where do silicone bleeds happen?
In silicone implants
What are silicone bleeds? Does it migrate anywhere?
- Microscopic leak contained in fibrous capsule
- Migrates to lymph nodes
What does silicone bleeds results in?
Lymphadenopathy
What is this an example of?
Silicone bleeds
What does contractures look like?
Capsule should be larger than the implant and flexible
With contracture, the fibrous capsule does what?
Contracts and constricts, disfiguring the breast
What is gynecomastia? 2
- Male breast enlargement
- Abnormal proliferation of glandular tissue and increased subcutaneous fat
What is gynecomastia linked to? 3
- Estrogen and androgen use
- Drugs for hypertension and depression
- Estrogenic neoplasms
How solid is the link to breast cancer for gynecomastia?
Unclear
What does gynecomastia look like? 3
- Enlarged breast
- Palpable firm mass under nipple
- Pain/ tenderness
What is the ultrasonic appearance of gynecomastia? 3
- Triangular area of hypoechoic glandular tissue under areolar region
- Ducts converging toward nipple
- Increased fat
What is this an example of?
Gynecomastia