Breast Management 15/02 Flashcards
1
Q
3 ways to detect breast cancer
A
Screening programme
Incidental
Symptomatic
2
Q
What are some of the symbols for triple assessment?
A
Examination (palpation): P Mammogram: M Ultrasound: U Cytology (FNA): C Histology (biopsy): B
3
Q
Score 1-5 malignancy
A
1 - Normal 2 - Benign 3 - Uncertain/likely benign 4 - Suspicious of malignancy 5 - Malignant
4
Q
Good prognostic factors
A
Size - T1/T2 Grade - grade 1 ER status - positive PR status - positive HER2 status - negative Histology - infiltrating ductal carcinoma Nodal status - negative Performance status - 0/1 Age - greater than 50 at diagnosis
5
Q
Bad prognostic factors
A
Size - T3/T4 Grade - grade 3 ER status - negative PR status - negative HER2 status - positive Histology - lobular or inflammatory cancer Nodal status - positive Performance status - 2/3 Age - less than 50 at diagnosis Triple negative (ER neg, PR neg and HER2 neg)
6
Q
What are the 3 primary treatment options?
A
Endocrine therapy, surgery, NACT (+herceptin)
7
Q
Who is endocrine therapy for?
A
- Typically for older patients who are not fit for surgery
- Poor performance status
- Surgery delayed
8
Q
Who is surgery for?
A
Most patients will have primary surgery unless others factors indicate other treatment needed first
9
Q
Who is neo-adjuvant chemotherapy for?
A
- Node positive
- Triple negative
- HER2 positive
10
Q
Who is herceptin for?
A
Given in conjunction with chemotherapy if HER2 positive
11
Q
What are the 6 triple assessment factors used to decide primary treatment?
A
- Tumour size
- ER status
- Herceptin receptor status
- Nodal status
- Histology
- Performance status
