Breast Lumps (non cancerous) Flashcards

1
Q

What is a fibroadenoma?

A

who gets it:
reproductive people
early 20’s. (COCP / pregnancy / menses)

what is it?
he most common benign growth. the proliferation of stromal/epithelial tissue of duct lobules. multiple and bilateral

clinical feautres:
small harmless breast tissue
hard  / well defined / rubbery
highly mobile (breast mouse)
usually 1-2cm in size (<5)
multiple/bilateral
may get bigger with time over the years

investigate: triple assessment. diagnose with US and clinical exam
manage: left insitu. consider excision if >3cm/>5cm, if >30 or FH (2ww)

biopsy if over 25 y/o to differentiate from phyllodes

large >5cm usually in pregnancy (hormones have caused rapid growth)

remove if troublesome:
Surgical lumpectomy
Excisional biopsy
Vaccum assisted biopsy
Cryoablation
High intensity focussed US for abltion of fibroadenoma tissue.
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2
Q

What is fat necrosis?

A

acute inflammation response in breast leading to ischaemic necrosis of fat lobules

trauma/previous surgical or radiological intervention
larger, fatty breast, obese. fat necrosis (deranged cell death caused by inflammation). foam cells and necrotic lipid material. lateral fibrosis and calcification.

usually asymptomatic, painless pump, skin changes, erythema, dimpling, burising. can develop into a solid irregular lump

blood test, imaging (USS), core needle biopsy. if malignancy excluded and no troubling symptoms= follow up
if symptomatic= surgical excision

Ix: USS hyperechoic mass. mammogram hyperdensity, calcification (Can mimic carcinoma)
histology to diagnose

mx: conservative

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3
Q

What is a breast cyst?

A

fluid-filled sacs in the breast
accumulation inside ethe glands. 35-50 (prenasal, rare in menopause unless HRT)

smooth, easily mobile
round or oval lump
tender on palpation
rapid onset
fluctuant

Ix: can’t distinguish from a solid tumour. ultrasound mammogram, aspirate

mx: FNA to test and treat
do not require tx unless persistent, large, painful
blood-stained or lump persists after aspirate= triple assessment

increased risk of breast cancer in younger pt

! if blood stained on aspiration= biopsy/excise

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4
Q

What is a Phyllode tumor?

A
rare fibroepithelial/stromal tumour
presents like a fibroadenoma (difficult to differentiate)
grow rapidly (3cm, next day 4cm)
*can be malignant
removed to stop recurring

40-50y/o
smooth and mobile lump

ix: triple assessment
mx: wide excision and follow up (potential to become cancerous)

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5
Q

What are breast buds?

A

puberty small swelling under nipple / areolar complex

supernumerary breast tissue can occur in axillar or upper abdo wall

An acute(usually bacterial) infection of the breast tissue
May be associated with fever, pus discharge from the nipple and local erythema, tenderness and heat
Treat with antibiotics. May require incision and drainage surgically.
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6
Q

What is gynaecomastia?

A

male breast tissue
one or both sides
breast disc/bud full bresat
puberty/older age

liver disease/meds
obestity/gym/aclohol/testicular cancer

reassure
surgery
tamoxifen- for pain?

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7
Q

What is a breast abscess?

A

collection of pus within the breast lined with granulation.
commonly develops from mastitis

causes:

  • post-partum (milk stagnating) encourage to express and breast feeding. *flucloxacillin
  • smoking- ductal abscesses. do not heal when smoking (blood supply)
  • nipple piercing (group B streptococcus, mycobacterium)

symptoms:
painful, swollen lump. swelling, erythema and heat overlying skin. systemic symptoms- fever, lethargy

Ix: USS if doubt of the diagnosis

punctum on surface

Mx: refer- surgical referral for drainage

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8
Q

summary of breast lumps ddx

A

cyst
pre-menopausal
HRT - maintains the lady in menopausal state

can be multiple, painful

fat necrosis- oil cyst forming from truama. lump uner the skin not in bresat tissue.

abscess- periductal mastitis.

mondor’s- thrombophlebitis cord. tx with NSAID’s

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9
Q

Lymph drainage

A

majority drainage- axillary

medial breast- parasternal / intrathoracic

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10
Q

What is a fibrocystic breast

this is the hormonal one

A

benign breast disorder
hormonal aetiology (around period)
breast composed of tissue that feels lumpy / rope-like in texture
worse with menstruation

fluid-filled round or oval sacs
a scar-like fibrous tissue
hyperplasia

2-0-50 y/o
rarely post-menopausal unless taking HRT

nodulariy/lumpy, pain or tenderness, pain week before menstruation, decreases after

ix: USS, mammography
mx: analgesia, good bra, refferal if persists

AKA physiological mastalgia- cyclical pain. usually affects the upper outer aspect of the breast

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11
Q

What is mastitis?

A

inflammation of breast tissue
infection (Staph aureus) but can be granulomatous

lactation- more common, first 3 months of breastfeeding or during weaning. cracked nipples, milk stasis, 1st child

non-lactational is less common but can occur in duct ectasia, a tobacco risk factor

  • painful breast (worse when breastfeeeding)
  • tenderness
  • swelling and erythema (wedge shaped)
  • fever, malaise, rapid onset, unilateral

symptoms/exam: tender, swelling or induration, erythema over the area of infection. red and swollen breast. tender.

Mx: systemic abx (flucloxacillin / erythromycin or clarithromycin if allergies) analgesia, encourage milk drainage/feeding to relieve blockage.

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12
Q

What is a galactocele?

A

a cyst containing retention milk in the mammary grams. obstruction of the lactiferous duct. lacteal cyst/milk cyst

less infective picture

during pregnancy, lactation
cessation of lactation

firm, painless breast lump
increases in size over time (week/months)
similar to a cyst on exam
not typically accompanied by tender, erythema or overlying skin

mx: self limtiing, referral

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13
Q

What is Modor’s disease?

A

like DVT in a vein in your breast. thrombophlebitis of the chest wall and breast.

rare 30-60
period tenderness with redness, the cord-like structure under skin, progress to form areas of fibrosis, less painful overtime

self-limiting, triple assessment

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14
Q

Accessory breast tissue

A

congenital condition
abnormal accessory breast tissue
more aware at puberty

symmetrical
typically at the axillary tail
tender related to the menstrual cycle
supernumerary nippples

no tx required
surgical excision to relieve discomfort.

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15
Q

Mastitis mx

A

manage with antibiotics
caused by infection (periductal infection / duct ectasia / perihperal infection)

can be associated with DM, RA, corticosteroid use.

oral co amoxiclav 500/125mg x 3 per day for 14 days

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16
Q

duct ectasia

  • symptoms
  • investigation
  • what is seen on biopsy?
  • what is seen on mammogram?
A

Benign
Smoking is a major risk factor
Nipple discharge, often blood stained
Mastalgia (non-cyclical)
Nipple inversion/retraction
Occasional associated with a palpable subareolar mass.
Treat conservatively and it often settles spontaneously.
If persists surgical excision is an option.

dilation/shortening of hte major lactiferous ducts
peri menopausal women
coloured green/yellow nipple discharge
palpable mass
nipple retraction

ix: mammogram shows calcified duct
biopsy: multiple plasma cells on histology

mx: conservative, unremitting nipple discharge

17
Q

intraductal papilloma

A

benign breast lesion
subareolar region
40-50
warty lesion behind areolar, <1cm away from the nipple. blood/clear nipple discharge

Usually present around the post menopause
Can present with a serous or bloody discharge from the nipple. Small (2-3mm) wart like lesion within a breast duct
They can obstruct the duct causing cysts or twist and become necrotic causing bleeding

Investigate with breast ductography (injection of contrast to visualise the breast ductal system).
Benign but can represent and increase risk of cancer

Treated mostly with surgical excision and vigilant breast screening. tx: microdochectomy?

18
Q

acessory breast tissue

A

congenital condition
abnormal accessory breast tissue
more aware at puberty

symmetrical
typically at the axillary tail
tender related to the menstrual cycle
supernumerary nippples

no tx required
surgical excision to relieve discomfort.

19
Q

periductal mastitis

A

ducts under the nipple become infected
pain, periareolar mass and discharge from the nipple
occurs in younger women
smoking is a risk factor

ultrasound in breast clinic
swab the discharge for microscopy and culture, FNA

staph aureus
staph eepidermidis
streptococci

abx: co-amoxiclav, flucloxacillin, surgical drainage.

20
Q

breast asbsess and sepsis

A

tachycardia
fever

requires immediate admission

RF: prev mastitis, immunosupression, poor hygine, staph aureus colonisation

empty abscess with US-guided aspiration. if refills then surgical incision and drainage is advised. (Scarring and complications)

21
Q

breast pain management

A

from breast or chest wall
cyclical/non-cyclical

therapeutic
primrose oil
EPO
NSAIDs
diet
exercise
bra 
OCP
danazol- increase testosterone
tamoxifen
groserelin
22
Q

nipple symptoms

A

inversion
supernumerary

discharge- color, stop expressing, normal duct ectasia

milking- prolactin

nipple discharge differentials:
mammary duct ectasia
intraductal papilloma
breast abscess

23
Q

Paget’s

A

eczema of the nipple (not of the breast or areolar)

cancer changes of DCIS- breaks through on the skin of the nipple so the nipple bleeds (this isn’t the same as bloody discharge) it ulcerates.

*eczema of the breast is different

24
Q

breast lymphatic drainage

A

75% to axillary nodes
20% to parasternal nodes
5% to posterior intercostal nodes

breast cancer metastasis through the lymph nodes. they become stony hard and fixed. from here, cancer can spread to the liver, lungs bones and ovaries.

25
Q

what is involved in the triple assessment?

A

hospital based assessment clinic
allows for early and rapid detection of breast cancer

mainstay to distinguish between lumps / cyst / abscess / maligancy

  1. breast exam
  2. imaging (ultrasound and mammogram)
  3. biopsy (mostly core biopsy)
26
Q

2 week wait

A

> 30 years with unexplained lump with or without pain

> 50 with discharge, retraction or any change causing concern

any skin changes
>30 unexplained lump in axilla

non urgent if <30 and unexplained with or without

27
Q

duct ectasia

A

dilation and shortening of the major lactiferous ducts

peri-menopausal women

coloured green/yellow nipple discharge, palpable mass, nipple retraction

IX:
mammogram, dilated calcified ducts
biopsy contains multiple plasma cells

conservative mx
duct excision if unremitting nipple discharge

28
Q

breast cancer

A

invasive

non invasive

29
Q

invasive

A

most common
hx of gradual breast enlargement
personal or fhx of breast cancer

hard, fixed mass
nipple inversion, discharge, skin retraction, peau d’orange, lymphadenopathy

management: triple biopsy

30
Q

non invasive (ductal carcinoma in situ)

A

asymptomatic

breast mass (not always)
nipple discharge
breast tenderness
cracking of skin 
triple assessment
31
Q

breast cancer in men

A
Increased age
Radiotherapy exposure
Family history of breast cancer
High oestrogen levels (liver cirrhosis and obesity)
Damage or malfunction of the testes

Presentation is similar to that of women
Most common is a lump
Can also gave nipple changes, discharge, bleeding or skin changes

Prognosis of breast cancer is worse in men due to less awareness causing a delay in initial presentation

Tamoxifen is often used for treatment

32
Q

reactive lymph node

A

young woman, after a viral flu like illness

pain in breast
general malaise and arthralgia
palpable lump in axillary tale / supraclavicular fossa

33
Q

tietze syndrome

A

inflammation of the costochondral junctions at the edfge of the sternum following a viral illness
(dry cough)