Breast Cancer Genetics - Nikcevich Flashcards
In breast cancer, what is the best way to stage the cancer?
Surgery (lumpectomy)
What patient population can Aromatase Inhibitors be used for in the treatment of breast cancer?
Only in POST-MENOPAUSAL women
aromatase inhibitors will induce menopause in pre-menopausal women
What information does the Oncotype Dx Breast Cancer Assay give you?
Quantitative Recurrence Score = read out (e.g. 11)
Qualitative Recurrence Score = percent (e.g. 7%, low risk)
Benefit of chemotherapy (yes/no, by how much - 1%)
How long is Tamoxifen used for in the treatment of breast cancer?
10 years
What is the most common quadrant of the breast to find a lump or tumor?
Upper/Outer Quadrant (UOQ)
What is the single most important treatment of breast cancer?
Hormonal Therapy (Tamoxifen/Aromatase)
What is mastalgia?
Breast pain
What diagnostic imaging test do you use if you can’t identify a suspicious area on mammogram or ultrasound?
MRI
What type of breast cancer CAN be silent on a mammogram?
Infiltrating (invasive) lobular carcinoma
What type of breast cancer do you use the Oncotype Dx Breast Cancer Assay for?
Stage 1/2 , ER+
don’t use on HER2+ => just assume high risk
What type of cancer is not treated with chemotherapy?
DCIS (just use radiation and tamoxifen)
How do you treat a male with breast cancer?
Same way you treat breast cancer in women! (surgery, hormonal therapy, chemotherapy, etc.)
***Need to get BRCA mutation testing!!!!
What are the three strategies to reduce the risk of breask cancer in high-risk patients?
Annual (or biannual) screening
Tamoxifen or Raloxifene (approximately 50% risk reduction)
Prophylactic mastectomy
How can you measure the risk of breast cancer in the clinic?
Gail Model (based on family, medical and clinical history)
