Breast Cancer Flashcards
What is a phyllodes tumour?
Very rare periductal cancer
What is shown on histology of phyllodes tumour?
Leaf-like pattern
DDx of a breast lump?
In situ carcinoma
- DCIS
- Invasive lobular
Phyllodes tumour
Fibroadenoma
Lipoma
What is a fibroadenoma and who gets them?
Most common breast lump in younger women
What are the characteristics of a fibroadenoma?
Non tender
Well circumscribed
Freely movable
What are protective factors of breast cancer?
Breast feeding
Early family
What are risk factors of breast cancer?
BRCA1, 2 Menopause TP53 PTEN \+FH HRT
Typical presentation?
” 68 y/o woman presents with a 3/12 history of painless lump in her upper lateral quadrant of her right breast. O/e the lump is hard and immobile. She has 3 enlarged axillary lymph nodes. “
What is the name of the lymph node that first drains a breast malignancy?
Sentinel node
What type of discharge might a ductal cell cancer present with?
Bloody
What skin sign may be seen on the breast?
Peau d’orange
What is peau d’orange?
Orange skin
Investigation of suspected breast cancer?
Mammogram
USS with FNA
What may be seen on mammogram?
Microcalcification
Irregular mass
What will a fibroadenoma look like on mammogram?
Regular, well defined border
What specific gene can be checked for in breast cancer?
HER-2
What else can be tested for about the cancer itself?
Hormone receptor testing
What is FNA used for?
Staging
Treatment of breast cancer?
Surgery
Chemo
Radio
What is preferred treatment of breast cancer with no nodal involvement?
Breast conserving surgery
Mastectomy
What is criteria for breast conserving surgery?
Tumour <4cm
What is treatment for breast cancer with affected sentinel node?
Mastectomy + node resection
What type of mastectomy can be done for breast cancer?
Skin conserving
What type of chemo can be done for HER-2 + breast cancer?
Herceptin
