Breast Cancer Flashcards
Epidemiology
Breast
Most common ca in women.
2nd cancer related death in women.
1 in 8 women will get BC.
Etiology
Breast
Gender (most significant) Age 40-70(55) Family history Genes BRCA1,2 Hormone factors Alcohol Radiation exposure
Prognostic factors
Breast
LN status most important (low risk fewer than 3; high risk 4+) Tumor size Presence of mets Histology ER PR HER2 status
Breast between which ribs
2-6 rib
Name of ligament that supports the breast
Cooper’s
Number of IM nodes
Breast
8 total
4 per side
Region most common in breast
Upper outer quadrant of left breast
Mets
Breast
Bone Lung Brain Liver Eyes Ovaries Adrenal and pituitary gland
Clin. Pres.
Breast
Painless lump (most common) Nipple discharge Nipple retraction, tenderness or pain Skin changes Alteration in breast contour Lymphadenopathy
Annual Mammogram should start at what age
40
Synonym for lumpectomy
Excisional biopsy
Histology
Breast
Infiltrating ductal carcinoma
Radical mastectomy
Entire breast with overlying skin.
All axillary nodes
Pectoral muscles
Modified radical mastectomy
Breast
Some or all axillary nodes
Pectoralis minor (optional)
Lumpectomy
Tumor plus margin
Chemo drugs
Breast
Cyclophosphamide
Doxorubicin (Adriamycin)
Paclitaxel
Hormone therapy
Breast
Tamoxifen
Aromitase inhibitors
Doses
Breast
45-50Gy plus boost to total of 60-66Gy to tumor bed
IM nodes tmt field
Breast
Tang field extended 3 cm beyond midline to Contralat side
Erythema occurs
30Gy (3-4 wks)
Dry desquamation occurs
40Gy
Moist desquamation occurs
After 50 Gy
Stage 1
Early disease: tumor confined to the breast (node negative)
