Breast cancer

Question 1

Describe the effect taking the COCP has on breast cancer risk

Answer 1

small increase in risk that returns to normal 10 years after stopping the pill

Question 2

what type of HRT increases breast cancer risk the most

Answer 2

combined HRT

Question 3

BRCA1 gene is on chromosome

Answer 3

17

Question 4

BRCA1 is associated with increased risk of what cancers

Answer 4

breast
ovarian
bowel
prostate

Question 5

BRCA2 gene is on chromosome

Answer 5

13

Question 6

BRCA2 gene is associated with increased risk of what cancers

Answer 6

breast
ovarian

Question 7

What is Paget’s disease of the nipple

Answer 7

Looks like eczema of the nipple/areolar
Indicates breast cancer involving the nipple

Question 8

mammograms are offered

Answer 8

every 3 years to women aged 50-70

Question 9

criteria for referral to secondary care based on family history of breast cancer

Answer 9

A first-degree relative with breast cancer under 40
A first-degree male relative with breast cancer
A first-degree relative with bilateral breast cancer, first diagnosed under 50 years
Two first-degree relatives with breast cancer

Question 10

options for chemoprevention of breast cancer in high risk women

Answer 10

tamoxifen if premenopausal
anastrozole if postmenopausal

Question 11

common sites of breast cancer metastasis

Answer 11

lungs
liver
bones
brain

Question 12

hormone treatment for premenopausal women with oestrogen receptor positive breast cancer

Answer 12

tamoxifen

Question 13

hormone treatment for postmenopausal women with oestrogen receptor positive breast cancer

Answer 13

aromatase inhibitors (letrozole, anastrozole or exemestane)

Question 14

monoclonal antibody that can be used in HER2 positive breast cancer

Answer 14

trastuzumab, pertuzumab, neratinib