Breast Cancer

Question 1

which gene mutations increase the risk of breast cancer?

Answer 1

BRCA1 (17q)

BRCA2 (13q)

Question 2

adjuvant therapy options

Answer 2

hormonal therapy
monoclonal Ab
bisphosphonates
SACT

Question 3

hormonal therapy options

Answer 3

ovarian ablation
tamoxifen
aromatase inhibitors

Question 4

when can hormonal therapies be used?

Answer 4

ER/ Pg +ve patients only

Question 5

SE of hormonal therapy

Answer 5

infertility
menopause
weight gain
endometrial cancer
DVT

Question 6

when is trastuzumab used?

Answer 6

HER2 +ve

Question 7

when are bisphosphonates used?

Answer 7

zolendronic acid
pamidronate
ibandronic acid
risedronate

Question 8

SE of bisphosphonates

Answer 8

osteonecrosis of jaw
renal impairment
atypical fractures

Question 9

mode of action of denosumab

Answer 9

monoclonal Ab that binds to RANKL on osteoclasts

Question 10

when is SACT used?

Answer 10

triple negative

Question 11

adverse of tamoxifen

Answer 11

VTE

endometrial hyperplasia

Question 12

adverse of aromatase inhibitors

Answer 12

OP

Question 13

indications for radiotherapy in breast cancer

Answer 13

WLE
DCIS
post mastectomy (large tumour >5cm, positive chest wall margins, post NACT and 4 or more axillary nodes)
axilla (if positive or irresectable disease)
SCF.