breast Flashcards

1
Q

Mobile, firm lump in a 27 year old woman

A

Fibroadenoma

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2
Q

Fibroadenoma may be mistaken for what?

A

Phyllodes tumour- fast growing fibroepithelial tumour

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3
Q

Fibroadenomas arise from what?

A

Breast lobule

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4
Q

Smooth, discrete fluctuant lump

A

Cyst

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5
Q

Management of fibroadenoma

A

Excise if >3cm

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6
Q

Investigation/management of breast cyst

A

aspirate, if blood stained or persistently refilling then biopsy and/or excise

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7
Q

Woman presents with a painful breast lump. A mammogram doesn’t rule out malignancy. What benign condition could it be?

A

Sclerosing adenosis

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8
Q

Does sclerosing adenosis increase risk malignancy?

A

Not premalignant lesion but may increase risk

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9
Q

What are the types of epithelial hyperplasia?

A

Ductal/Lobular

Typical/atypical

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10
Q

Does epithelial hyperplasia= increased risk breast cancer?

A

if atypical and FHx breast ca yes

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11
Q

Green discharge from nipple and tender lump around areola?

A

Mammary duct ectasia

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12
Q

What can occur if mammary duct ectasia ruptures?

A

Plasma cell mastitis (local inflammation)

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13
Q

Blood stained discharge from nipple

A

Duct papilloma

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14
Q

Eczematous reddening and thickening of areola/nipple

A

Paget’s disease- intraductal carcinoma

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15
Q

What is fibroadenosis/fibrocystic disease/benign mammary dysplasia?

A

Lumpy breasts

35-50yo

Spectrum of histological changes

May be normal overgrowth

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16
Q

Does fibroadenosis/fibrocystic disease/benign mammary dysplasia have increased risk Ca?

A

Only if marked epithelial hyperplasia

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17
Q

Obese woman with history of trauma to breast presents with a growing tethered lump

A

Fat necrosis (or cancer- image and biopsy)

18
Q

Differentials for bloody discharge from nipple?

A

Duct papilloma

DCIS (incl paget’s)

Mammary duct ectasia

19
Q

What is a common cause of mastitis?

A

Milk stasis

20
Q

What is an important non-pharmacological step in the management of mastitis?

A

frequent and regular milk removal- may avoid need for antibiotics

21
Q

Most common pathogen in masititis

A

staph aureus

22
Q

Painful swollen lump in breast with red, hot overlying skin (and history of mastitis)

23
Q

Severe, deep, burning pain in mastitis might indicate what?

A

Ductal infection

24
Q

When should you send a breast milk M,C and S in mastitis?

A

If severe, deep, burning pain (ductal infection), severe or recurrent mastitis or if hospital acquired infection

25
Management of breast abscess
Urgent referral to surgeon for USS, drainage and culture for Abx
26
Should women with mastitis/abscess continue breast feeding?
Yes if pain allows, if not then express milk
27
What is the oestrogeny risk factor for breast ca?
Uninterrupted oestrogen exposure
28
What might peau d'orange indicate?
Mastitis Inflammatory breast cancer- v bad!
29
Where is oestrogen produced pre and post menopause?
Pre- ovaries Post- fat/muscle/liver/skin/breast
30
How does tamoxifen work and who is it given to (pre/post menopause)
Given to all Competitively binds to the oestrogen receptor site on the cancer
31
What is a pre-menopause hormonal therapy for breast ca?
Oophorectomy (stop oestrogen production)
32
What is a post-menopause hormonal therapy for breast cancer?
Aromatase inhibitors- block extra-ovarian oestrogen production e.g. anastrazole
33
what do HER2 receptors do?
Tell cancer to grow
34
How does herceptin work?
Blocks HER2 receptors
35
What type of therapy is herceptin?
Targeted
36
SE of herceptin?
cardiotoxic
37
What is the 'best' cancer to have in terms of ER/PR/HER positivity/negativity?
ER/PR positive- responds to hormone Rx
38
What is the 'worst' cancer to have in terms of ER/PR/HER positivity/negativity?
Triple negative - ER/PR/HER neg. Harder to treat. Often BRCA1
39
pros/cons of a HER2 positive cancer?
Aggressive cancer but responds to herceptin
40
Is phyllodes tumour malignant?
Can be benign/borderline/malignant but all have malignant potential so excise
41
In whom does phyllodes tumour present?
40-50yo