Breast Flashcards

1
Q

From what does a breast abscess arise?

A

Severe mastitis

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2
Q

What organism is most common in breast infection?

A

Staph aureus

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3
Q

What usually causes mastitis?

A

Milk stasis during lactation

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4
Q

What would be the treatment of a breast abscess?

A
  • Antibiotics e.g. flucloxacillin or erythromycin
  • Incision and draining of abscess
  • Needle aspiration of abscess every other day
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5
Q

Should lactating women with a breast abscess continue to breastfeed?

A

Yes

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6
Q

How common is fibrocystic disease amongst women of childbearing age?

A

50%

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7
Q

How does fibrocystic disease of the breast present?

A
  • Lumpiness and tenderness

- itchy nipples

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8
Q

What kind of trend do the symptoms of fibrocystic disease follow?

A

Periodic trend of the menstrual cycle

Usually worse before period

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9
Q

What does the breast look and feel like on examination of fibrocystic disease?

A
  • lumpy, cobblestone appearance
  • smooth lumps with defined edges that are moveable
  • most commonly in upper, outer sections of breast
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10
Q

What investigations would you do on someone presenting with fibrocystic disease (depending on their age)?

A
  • Mammography for older patients

- Ultrasound for younger patients

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11
Q

What is thought to cause fibrocystic disease?

A

Hormone levels - oestrogen, progesterone, prolactin
These hormones cause breast cells to grow and multiply
Fluctuations of hormones over years cause small cysts and dense tissue

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12
Q

What is a ductal papilloma?

A

A benign growth that occurs in breast ducts with finger-like fronds that can block the duct

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13
Q

Which type of ductal papilloma is more common near menopause?

A

Central type - near nipple and solitary

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14
Q

Which type of ductal papilloma is more common in younger women

A

Peripheral type

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15
Q

Which type (central or peripheral) of ductal papilloma has higher risk of malignancy?

A

Peripheral type

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16
Q

What changes occur in the breast in ductal papilloma i.e. how does it present?

A
  • Bloody nipple discharge

- Wart-like growth

17
Q

What is the name for the removal of a breast duct?

A

Microdochectomy

18
Q

What investigation do you do for ductal papilloma?

A

Galactogram = radiography of ducts after injection of an agent

19
Q

Why is ultrasound scan used over mammography for ductal papilloma?

A

They are too small to be seen on mammography

20
Q

What genes predisposes you to breast cancer?

A

BRCA1 and BRCA2

21
Q

What chromosomes are the BRCA1 and BRCA2 genes found on?

A
BRCA1 = Chromosome 17
BRCA2 = Chromosome 13
22
Q

What 2 types of breast carcinoma are there?

A

Ductal carcinoma = epithelial lining of ducts

Lobular carcinoma = epithelium of terminal ducts of lobules

23
Q

What is Paget’s disease of the breast?

A

Infiltrating carcinoma of nipple epithelium

24
Q

What growth factor receptor gene is commonly over-expressed in breast cancer?

A

HER2 growth factor receptor gene

25
Q

Does the presence of HER2 mean it is a more/less aggressive disease?

A

More aggressive disease if HER2

26
Q

Other than BRCA1 genes, family history and age, what are some risk factors for breast cancer?

A
  • Nullparity
  • First child after 30
  • Early menarche or late menopause
  • HRT
  • Obesity and alcohol
27
Q

All breast lumps must undergo ‘triple assessment’. What does this mean?

A

Clinical examination
Histology/cytology
Mammography/ultrasound

28
Q

What lymph nodes are commonly affected in breast cancer?

A

Axillary nodes

29
Q

What would the lump be like on examination in breast cancer?

A

Hard, painless lump with irregular margins

Fixed to skin/chest wall

30
Q

What skin changes would you see on the breast in breast cancer?

A

Peau d’orange = oedema due to lymphatic invasion from tumour

Skin dimpling

31
Q

What is the current screening programme for breast cancer?

A

All 50-70 year old women
Every 3 years
Mammography

32
Q

What is the surgical treatment of breast cancer?

A

Either wide local excision or mastectomy +/- axillary node clearance