Breast Flashcards
what are the most common ways people come to breast clinic
breast lump
breast pain
what dos you need to ask if someone says breast pain
cyclical, unilateral, bilateral
why is a history of lymphoma important?
mantle cell radiotherapy
chest wall radiotherapy - increases risk of breast cancer
why do under 40s get USS not mammogram
not through menopause
breasts more dense
what is breast involution
breast after menopause and pregnancy closes back up
what are the 2 serious side effects of tamoxifen
why is it not really used
uterine cancer and VTE
what are the 5 main genes which can cause breast cancer
BRCA1, BRCA 2, PALB2, ATM and CHEK2
what risk assessment model can be used to see if genetics can be a risk for breast cancer
Tyrer-chekov
how does tamoxifen work
competitively binds to oestrogen receptors on tumours
what are main side effects of tamoxifen
Hot flushes
Vaginal discharge
G.I. Disturbance
Weight gain
Bone density loss/gain
Endometrial cancer
VT
what is the Oncotype DX test
Genomic test profiling individuals tumour tissue
what is the drug given which is monoclonal antibodies against HER2
herceptin
who is Oncotype DX test offered to
every woman diagnosed with breast cancer
how often is a heart ultrasound done for a patient receiving Herceptin
USS every 3 months for the heart
- risk of cardiotoxicity
what is the criteria for NHS BSP screening
Women 50 – 70
2 view mammography
3 yearly
