Breast

Question 1

Trastuzumab

Answer 1

HER2 monoclonal antibody

Question 2

Management of fibroadenoma

Answer 2

Core biopsy

<4cm –> D/C

> 4cm –> Excise

Question 3

Chromosome 17

Answer 3

BRCA 1

p53

Question 4

BRCA 2

Answer 4

Chromosome 13

Question 5

PTEN

Answer 5

Chromosome 10

Question 6

BRCA 1

Answer 6

Chromosome 17

Question 7

Duct ectasia

Answer 7

Shortening and dilitation of the ducts

Slit-like nipple retraction

Mx
-Conservative
-Surgery if patient wishes

Question 8

Duct Papilloma

Answer 8

Blood-stained discharge from papilloma in single duct
Can be serous discharge

Mx
Microdeochectomy (removal of single discharging duct)

Question 9

Phyllodes tumour

Answer 9

Fibro-epithelial neoplasm
Mostly benign, can be cancerous

Localised discrete mass

Mx
WLE
Mastectomy if required

Question 10

Polands syndrome

Answer 10

1. Abnormalities of pecoralis muscle
2. Upper limb abnormality
3. Hypoplasia/ absence of breast

Question 11

Lymph stages of breast

Answer 11

Pectoralis minor stages

1: lateral to pec minor

2: beneath pec minor

3: medial to pec minor

Question 12

Adjuvant chemotherapy

Answer 12

At least 4 cycles

Adriamycin
Cyclophosphamide

OR

5-fluorouracil, epirubicin and cyclophosphamide

Question 13

Complications of breast surgery

Answer 13

Intercostobrachial nerve: numbness and paraesthesia down upper inner arm

Long thoracic nerve: serratous anterior, winging of scapula

Thoracodorsal nerve: atrophy of the latissimus dorsi muscle

Frozen shoulder

Lymphoedema from axillary dissection