Breast

Question 1

Luminal A breast cancer

Answer 1

ER positive
PR positive
HER2 negative
Ki67 low

Lower grade, better prognosis
Generally - up front surgery

Question 2

Luminal B

Answer 2

ER positive
PR positive or negative
HER2 positive
Ki68 any (>14%)

Worse prognosis than luminal A
Institute dependent
- surgery upfront unless reduced disease to wle

Question 3

HER2 enriched

Answer 3

ER negative
PR negative
HER2 positive

Worse prognosis than luminal cancers, targeted HER2 therapy
Chemotherapy up front

Question 4

Triple negative or basal-like breast cancer

Answer 4

ER negative
PR negative
HER2 negative

More common in patients with BRCA1 mutation, younger patients
More aggressive than luminal types
Chemotherapy up front

Question 5

Prognosis RCB

Answer 5

Residual cancer burden 0-1: very good
Residual 3: very poor

Question 6

Lobular carcinoma in situ on core

Answer 6

Management
- non classic: surgical excision
- classic: observation

Post excision
- non classic: re excision
- classic: no re excision