bread and butter Flashcards
drugs increasing lithium levels
[ ] Ace increases [ ] Loop increases [ ] Spiro increases [ ] Ibuprofen increases [ ] Mtx increases
drugs causing gingival hyperplasia
[ ] Ccbs
[ ] Cilosporin
[ ] Phenytoin
antidote to loperamide
naloxone
antidote to heparins
protamine sulphate
antidote to benzodiazepines
flumazenil
antidote to dabigatran
idrucizumab
antidote to apix and rivarox
andexanet alpha
antidote to digoxin
digoxin specific antibody
antidote for methotrexate
colonic acid
calcium foliate
QTP?
[ ] Amiodarone [ ] Sotalol [ ] Macrolides [ ] Haloperidol [ ] Ssrus citala and escit [ ] Tcas [ ] Antifungals [ ] Rlccbs [ ] Atomoxetine [ ] Methadone [ ] Domperidone [ ] Tacrolimus [ ] All SABA/LABAs [ ] Quinolones
what juice does warfarin interact with
cranberry and pomegranate
what juice does Amiodarone interact with
grapefruit
what juice do statins interact with
grapefruit
what juice do SSRIs interact with
grapefruit
what juice does ciclosporin interact with
purple grape,grapefruit and pomelo
what juice does tacrolimus interact with
grapefruit,pomelo and pomegranate
CYP450 substrates
[ ] Statins [ ] Amiodarone [ ] Digoxin [ ] Montelukast [ ] Warfarin [ ] Theophylline [ ] Benzos [ ] Ssris [ ] Tca [ ] Sildenafil (inhibitors) [ ] Tamsulosin (inhibitors) [ ] Sumatriptan
drugs lowering seizure threshold
[ ] Theophylline [ ] Tramadol [ ] Quinolones (ibuprofen) [ ] Lithium [ ] Antiepileptics [ ] Orlistat [ ] Chlorquine [ ] Mefloquine
drugs causing serotonin syndrome
[ ] Tramadal [ ] Triptans [ ] Lithium [ ] Ssris [ ] Tcas [ ] Maois [ ] Bupropion [ ] Linezolid [ ] Snris ( venlafaxine)
Drugs causing SJS
[ ] Phenytoin [ ] Carbamazepine [ ] Lamotrigine [ ] Galantamine [ ] Vancomycin [ ] Co-trimoxazole
hepatotoxic drugs
[ ] Itraconazole and antifungals (ketaconazole the most) [ ] Alcohol [ ] Amiodarone [ ] Macrolides [ ] Benzos [ ] Carb pheny valproa [ ] Maoi a phenel and isocarboxazid [ ] Atomoxetine [ ] All tb meds except ethambutol [ ] Flucloxicillin [ ] Chloramphenicol [ ] Nitrofurantoin [ ] Tetracyclines [ ] Terbinafine [ ] Mtx [ ] Sulfasalazine [ ] Mesalazine
drugs causing pancreatitis
[ ] Glutides
[ ] Gliptins
[ ] Valproate
[ ] Carbimazole
drugs causing suicidal ideation
[ ] Finasteride
[ ] All antiepileptics
[ ] Atomoxetine
[ ] Varenicicline
drugs causing neuropsychiatric reactions
[ ] Mefloquine
[ ] Isotretonoin
[ ] Montelukast
[ ] Quinolones
checking lithium levels after?
12 hours
check digoxin levels after?
6 hours
checking gent levels (MDD and ODD)
MDD: after 3-4 doses and at dose changes
ODD: 20 hours post dose
carbamazepine levels after?
1-2 weeks
theophylline levels?
4-6 hours post dose of mr formulation
5 days after initation and 3 days after any dose changes
drugs to avoid tyramine rich foods?
MAOIs
isonazid
linezolid
drugs causing neuroleptic malignant syndrome?
all APs
donepezil
with or after food?
metronidazole
nitrofurantoin
clarithromycin MR
empty stomach
[ ] Phenoxymebthylpenicllin
[ ] Tetracycline/oxyteyracyclime
[ ] Flucloxicillin
[ ] Azithromycin- capsules only
drugs causing ototoxicity
[ ] Clarightromycin and other macrolides [ ] Cisplatin [ ] Linezolid [ ] Vancomycin [ ] Vinca alkaloids [ ] Gentamicin
drugs causing photosensitivity
[ ] Doxycycline [ ] Isotretenoin [ ] Tacrolimus [ ] Amiodarone [ ] Ciclosporin [ ] Quinolones
drugs causing blood disorders?
[ ] Tacrolimus [ ] Co-trimoxazole [ ] Sulfasalazine [ ] Mesalazine [ ] antiepileptics
tacrolimus interacts with? (an important one)
macrolides
what colour does nitrofurantoin turn your urine
yellow brown
rifampicin colour
red
entacapone colour
brown red
traimterene colour
blue
Senna urine colour
yellow brown
chlorhexidine
stains teeth brown
POM to P?
PPI Chloramphenicol mometasone sildenafil maloff amrolofine sumatriptan tamsulosin tranexamic acid orlistat
drugs causing BMS
mycophenalate
all cytotoxic except bleomycin and vincas
drugs reducing intestinal mobility
[ ] Loperamide
[ ] Codeine
[ ] Metoclopramide
drug causing chug Strauss
montelukast
avoid antacids
tetracyclines
quinolone
bisphosphonates
drugs causing diarrhoea:
colchicine antibiotics laxatives magnesium ant acids digoxin
CALMD
Drugs causing constipation
al antacids AMs AHs AEs verapamil clozapine- refer
treating vertigo and tinnitus
betahistine
pregnancy nausea
cyclizine and prochlorperazine
treating an acute asthma attack in community
pMDI large volume spacer
4pu initially then 2 every 2 minutes for up to 10 puffs
can repeat every 10 minutes- 20 minutes
children: 1 pu every 30-60 seconds up to 10 puffs
breath accuated?
slow and steady over 4 s
DPI breathing
quick and deeply
pMDI breathing
slow and steady
potency of:
betametasone valerate
potent
potency of:
clobetasol propinate
very potent
potency of clobetasone butyrate
moderate
potency of hydrocortisone
mild
potency of nerisone forte?
very potent