Brachial Plexus and Shoulder Region & Development of the Limb Flashcards

1
Q

What are the different areas of the brachial plexus?

A
Roots: C5-8 and T1
Trunks: superior, middle and inferior
Divisions: anterior and posterior
Cords: lateral, posterior and medial
Branches: musculocutaneous nerve, median nerve, axillary nerve, ulnar nerve and radial nerve. There is also the long thoracic nerve and the medial and lateral pectoral nerves.
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2
Q

What are the important blood vessels in the axilla/upper arm region.

A

The subclavian artery becomes the axillary artery and then the brachial artery in the arm. The subclavian vein forms from the axillary vein, the main tributaries of which are the cephalic vein, which is lateral and the brachial and basilic veins.

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3
Q

What is the coracobrachialis muscle’s function? Where does it arise and insert and by what is it innervated?

A

The coracobrachialis helps to flex the shoulder joint and also adducts the humerus. It arises from the coracoid process of the scapula and inserts on the humerus. It is innervated by the musculocutaneous nerve.

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4
Q

Where does the serratus anterior arise and insert, what is its function and by what is it innervated?

A

The serratus anterior muscle arises from the side and front of the first 8 ribs, runs back under the scapula and inserts along its medial border. It can pull the scapula forward over the rib cage (protraction) and can rotate it downward and upward. It is innervated by the long thoracic nerve.

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5
Q

Where does the pectoralis minor arise and insert, what is its function and which nerve supplies it?

A

The pectoralis minor arises from the 3rd-5th ribs and is inserted on the coracoid process. It can cause depression of the scapula - can draw inferiorly and anteriorly and it raises the ribs in inspiration. The medial pectoral nerve innervates it.

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6
Q

What is the function of the pectoralis major, where does it arise and insert and what innervates it?

A

The pectoralis majorarises from the anterior border of the medial half of the clavicle and sternocostal head and inserts into the lateral lop of the bicipital groove of the humerus. Innervated by the lateral and medial pectoral nerves, it flexes and extends the humerus and adducts and medially rotates the humerus. It also draws the scapula inferiorly and anteriorly.

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7
Q

The deltoid muscle covers the shoulder, where does it arise and insert, what are its function and which nerve serves it?

A

The deltoid muscle’s origin is the lateral end of the clavicle and spine of the scapula and it inserts into the deltoid tuberosity of the humerus. Innervated by the axillary nerve, it plays a role in shoulder abduction, flexion and extension.

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8
Q

What is the axilla?

A

The area under the glenohumeral joint, at the junction of the upper limb and the thorax. 3D shape is like a pyramid.

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9
Q

What is the anatomical superior boundary of the axilla?

A

The opening at the apex/axillary inlet is formed by the lateral border of the 1st rib, superior border of the scapula and the posterior border of the clavicle.

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10
Q

What is the lateral wall of the axilla formed by?

A

The intertubercular groove of the humerus.

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11
Q

What does the medial wall of the axilla consist of?

A

The serratus anterior and the thoracic wall.

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12
Q

What does the anterior wall of the axilla contain?

A

The pectoralis major and underlying pectoralis minor and subclavius muscles.

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13
Q

What is the posterior wall of the axilla formed by?

A

Subscapularis, teres major and latissimus dorsi.

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14
Q

What are the main contents of the axilla?

A

Axillary artery, axillary vein (2 largest tributaries are basilic and cephalic veins), brachial plexus, biceps brachii, coracobrachialis, axillary lymph nodes.

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15
Q

What’s the clinical importance of the axillary lymph nodes? What’s axillary clearance and state an associated risk?

A

They filter lymph drained from the upper limb and the pectoral region. In women, an enlargement in a nonspecific indicator of breast cancer and it can be biopsied if this is suspected. Axillary clearance is when the nodes are removed to prevent cancer spreading. If the long thoracic nerve is damaged in this procedure, a winged scapula can result.

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16
Q

Which roots does the long thoracic nerve stem from?

A

C5, C6 and C7.

17
Q

Where do the medial and lateral pectoral nerves stem from?

A

The medial pectoral nerve stems from the medial cord of the brachial plexus, which came from anterior division of the inferior trunk and roots C8 and T1.
The lateral pectoral nerve stems from the lateral chord, which came from the anterior divisions of the superior and middle trunk and so roots C5, C6 and C7.

18
Q

How do you remember which roots the nerves of the arm stem from?

A
Labelling each digit C5 to T1 starting with the thumb:
5 rats - radial
3 musketeers - musculocutaneous
4 men - median
Assassinated - axillary
2 unicorns - ulnar.
19
Q

When in development do limb buds appear?

A

Towards the end of the 4th week. (CVS and CNS come first)

20
Q

Why do the lower limbs lag ~ 2 days in their development?

A

The progression is cranial to caudal.

21
Q

What is the limb bud made of?

A

A core of proliferating mesenchymal cells as flexible mesoderm with an ectoderm covering.

22
Q

What is the AER?

A

The apical ectoderm also ridge is the thick covering at the apex of the limb bud, made of ectoderm tissue, which is critical for limb bud growth by orchestrating development proximal to distal, finally regressing after the appearance of paddles.

23
Q

What are the 3 spacial axis in limb development providing asymmetry and what causes it in each case?

A
  1. Shoulder to fingertip/proximal to distal asymmetry caused by the AER.
  2. Palmar to dorsal surface/dorsal to ventral axis caused by the ectoderm.
  3. Side to side/anterior to posterior asymmetry controlled by ZPA.
24
Q

What does the AER do?

A

Exerts an inductive influence on immediately underlying mesoderm, keeping it undifferentiated, but proximal tissue will begin to differentiate into constituent tissues. Induces development of digits.

25
Q

What is the ZPA and what does it do?

A

The zone of polarising activity generates anterior-posterior asymmetry (left to right). It’s a signalling centre located at the posterior base of the limb bud, which controls patterning and maintains AER.

26
Q

How does the hand paddle go from flattened and flared to a recognisable hand?

A

Mesenchyme tissue within plates make cartilaginous models of digital rays, then progressive sculpting sees apoptosis of tissue between digits.

27
Q

What is syndactyly and what types are there?

A

Syndactyly is fusion of digits which can either by cutaneous or osseous.

28
Q

What is polydactyly?

A

Extra digits, caused by a recessive genetic trait.

29
Q

What’s the difference between Amelia, Meromelia and Phocomelia?

A

Amelia is complete absence of a limb whereas Meromelia is the partial absence of one or more limb structures and Phocomelia sees the hands/feet attached directly to the trunk of the body.

30
Q

What are the three underlying issues in morphogenesis?

A
  1. Malformation - intrinsic error in coordination of morphogenesis.
  2. Deformation - constriction bands causing genetically normal tissue of limbs to be truncated.
  3. Disruption - external agent e.g. Thalidomide (teratogenic agent), which disrupts AER so there’s poor elongation.
31
Q

Which spinal segments do the limbs appear opposite?

A

Upper limb buds appear opposite caudal cervical spinal segments whereas lower limbs develop opposite the lumbar and sacral spinal segments.

32
Q

Myogenic precusors migrate into the limbs from somites and coalesce in which 2 common muscle masses around newly formed skeletal elements?

A

Ventral - flexor

Dorsal - extensor

33
Q

Limbs extend ventrally at first, but as they elongate, they rotate. In which direction to the upper and lower limbs rotate?

A

Upper limbs rotate laterally and lower limbs rotate medially.

34
Q

What are the positions of the upper and lower limbs before and after rotation?

A

Before: thumbs up, elbows out and soles facing each other, with knees out.
After: thumbs out, elbows down and soles down, knees up.