Botulinum Flashcards
1
Q
How does botulinum produce effects
A
Target neurones of the autonomic ns
Bind to high affinity peripheral cholinergic nerve terminals, enters cytoskeleton and cleave SNARE proteins blocking release of NT
Most neurotoxins - block presynaptic release of ACh at NMJ
2
Q
4 sites in the body botulinum attacks
A
NMJ
Autonomic ganglia
Post ganglionic parasympathetic nerve endings
Post ganglionic sympathetic nerve endings
