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deals with a drug’s actions as it moves through the body.
Pharmacokinetics
pharmacokinetics discusses how a drug is:
-Absorbed (taken into the body)
-Distributed (moved into various tissues)
-Metabolized (changed into a form that can be excreted)
-Excreted (removed from the body).
This branch of pharmacology is also concerned with a drug’s onset of action, peak concentration level, and duration of action.
Pharmacokinetics
covers a drug’s progress from the time it’s administered, through its passage to the tissues, until it reaches systemic circulation.
ABSORPTION
- On a cellular level, drugs are absorbed by several means
through active or passive transport.
is the process by which the drug is delivered from the systemic circulation to body tissues and fluids.
DISTRIBUTION
Distribution of an absorbed drug within the body depends on several factors
- blood flow
- solubility
- protein binding
other term for drug metabolism
biotransformation
is the process by which the body changes a drug from its dosage form to a more water-soluble form that can then be excreted.
METABOLISM
are capable of exerting their own pharmacologic action. may undergo further metabolism or may be excreted from the body unchanged
active metabolites
products of metabolism), which are then excreted.
inactive metabolites
excretion refers to the elimination of drugs from the body
EXCRETION
where are drugs mostly excreted
Kidneys through urine
lungs, exocrine (sweat, salivary, or mammary,glands, skin and intestinal tract
The study of the drug mechanisms that produce biochemical or physiologic changes in the body. The interaction at the cellular level between a drug and cellular components, such as the complex proteins that make up the cell membrane, enzymes, or target receptors, represents drug action. The response resulting from this drug action is the drug effect.
PHARMACODYNAMICS
- The use of drugs to treat disease
PHARMACOTHERAPEUTICS