Bone + Soft Tissue Tumours Flashcards
What is the most common benign bone tumour?
Osteochondroma
What is an osteochondroma and who gets them?
Bony outgrowth on the external surface with a cartilaginous cap
Age 10-20
What does an osteochondroma look like on xray?
Pedunculated bony outgrowth
What is the management of an osteochondroma?
Only needs to be excised if growing or painful
What is an enchondroma?
Intramedullary, metaphyseal, cartilaginous tumour
Caused by failure of normal endochondral ossification at growth plate
What does an enchondroma look like on xray?
Lucent oval + intact cortex
What is the management for an enchondroma?
If risk of impending fracture –> curettage + filled with bone graft
What is another name for osteoclastomas?
Giant cell tumours
What are osteoclastomas?
Giant cell tumour of epiphysis of long bones
–> pain, swelling and limitation of joint movement
What do osteoclastomas look like on xray?
Eccentric lytic area giving a ‘soap bubble’ appearance
What is the management of osteoclastomas/giant cell tumours?
Surgical resection
What are osteoid osteomas and how do they present?
Small tumours at metaphysis of long bones
Males ages 10-20
Localised progressive pain, worse at night
What do osteoid osteomas look like on xray?
Small lucent nidus surrounded by halo of reactive bone
What is the management of osteoid osteomas?
Conservative with NSAIDs for bone pain or
Surgical resection
What is a simple bone cyst?
Benign, fluid filled cyst
Metaphyseal in long bones, talus or calcaneus
What is an aneurysmal bone cyst and how is it managed?
Cyst containing multiple chambers filled with blood or serum
Locally aggressive causing cortical expansion + destruction
Painful + risk of fracture
–> curettage + grafting/bone cement
Which cancers commonly metastasise to bone?
Prostate Breast Kidney Thyroid Lung (PbKTL)
What is the general management of bony mets?
Palliative usually
Can prophylactically nail long bones at risk of fracture
What type of bony lesions does prostate cancer cause?
Sclerotic
What type of bony lesions does breast cancer cause?
Can be sclerotic or lytic
What type of bony lesions does lung cancer cause?
Lytic
What type of bony lesions does renal cancer cause?
Large, vascular, lytic ‘blow out’ lesions
How do primary bone cancers present?
Often misdiagnosed as muscular pain (present late)
Bone pain, worse at night/unexplained persistent pain
May be ill-defined bony swelling
What is the most common cause of malignant bone tumour?
Metastases from other cancers
What is the most common primary bone cancer?
Osteosarcoma
What age is osteosarcoma most commonly seen?
Age 10-14 or
> 65 due to Paget’s disease
What is the clinical presentation of osteosarcoma?
Localised constant pain + tender soft tissue mass
Most commonly at metaphysis of distal femur or proximal tibia
What does osteosarcoma look like on xray?
Medullary and cortical bone destruction
+ significant periosteal reactions
–> Codman’s triangle or ‘sunburst’ pattern
What is the management of osteosarcoma?
Biopsy to confirm
Aggressive surgical resection + chemotherapy
What is a chondrosarcoma?
Cartilage producing tumour of axial skeleton (pelvis, shoulders, ribs) –> painful enlarging mass
Less aggressive than osteosarcoma
What age group most commonly get chondrosarcomas?
Age 40-60
What do chondrosarcomas look like on xray?
Lytic lesions with calcification, cortical remodelling + endosteal scalloping
What is Ewing’s sarcoma?
Paediatric malignancy with poor prognosis
Arise from primitive poorly differentiated neuroectodermal cells in diaphysis of long bones
What is the clinical presentation of Ewing’s sarcoma?
Painful, enlarging, tender, warm mass
–> often mistaken for osteomyelitis
What does Ewing’s sarcoma look like on xray?
Lytic lesion + periosteal reaction –> onion skin
How can lymphoma affect bone?
Primary bone tumour from marrow --> Non Hodgkins Or lymphoma (any type) can metastasise to bone
Which other cancer might present with bone lesions?
Myeloma
What is the most common soft tissue tumour?
Lipoma
What is a lipoma?
Benign proliferation of subcutaneous fat
–> soft fatty lump under skin
Dos not need excised
What is a ganglion cyst?
Lump near a joint capsule or tendon sheath
Not a true cyst - no epithelial lining
Well defined, firm, transilluminate
Where are some common sites for ganglion cysts?
Due to arthritis/joint damage:
- wrist
- Baker’s cyst in knee
- Mucous cyst of DIP joint