Bone marrow transplant Flashcards
What is autologous vs allogeneic stem cell transplant
Autologous - from slef
Allogeneic - someone else eg family member, random public match, umbilical cord, parent and other relatvies
Conditioning in HSCT
Chemo +/- radio and then return of stem cells in autologus
Why do bone marrow transplatn
Haematological malignancies
RCC disorders eg sickle cell disease
Immunodeficiencies
Other
Process behind transplant
Identify donor/harvest stem cells
Hospital admission -> chemo+/=radio
Stem cell return - given like blood transfuion vis hickman line
Await engrafment
Major risks of HSCT
Side effects of chemo
Infection
GvHD - HLA
Relapse
Acute GvHD
Skin
GI tract
liver
What do symptoms of chronic GvHD mimic
autoimmune eg joint stiffness etc
Who are less likely to relapse w GvHD
Transplants for cancer eg ALL
Adult malignant transplants prognosis
10-20% mortality from transplant
30% disease relapse
What is upper limit age for transplant
70
