Bone Health Regulation Flashcards

1
Q

Bone mass peaks by what age?

A

Mid-20’s

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2
Q

How long does someone maintain their bone mass after reaching their peak?

A

10 years

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3
Q

After age 35, both men and women will lose ____-____% of their bone density per year. What is this part of?

A

0.3-0.5; the aging process

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4
Q

Less than ___% of bone loss during lifespan occurs before menopause.

A

50%

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5
Q

What accelerates bone loss rapidly in first postmenopausal decade?

A

Estrogen deficiency

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6
Q

Define bone turnover

A

Rates of deposition and absorption are equal so that total mass remains constant.

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7
Q

Bone turnover=

A

Remodeling

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8
Q

What percentage of bone mass turns over in a single year?

A

15%

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9
Q

What is the normal range of plasma calcium?

A

8.5-10.5 mg/dl

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10
Q

Describe what happens in hypocalcemia.

A

Increased neuromuscular excitability

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11
Q

Hypocalcemia results in increased neuronal membrane permeability to _____

A

Sodium

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12
Q

Hypocalcemia side effects

A

Muscle spasms, tetany, cardiac dysfunction

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13
Q

Tetany occurs at what plasma calcium level

A

6 mg/dl

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14
Q

Hypercalcemia results in _____ nervous system and muscle activity.

A

Depressed

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15
Q

Hypercalcemia occurs at what plasma calcium level?

A

12 mg/dl

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16
Q

Describe hyperpcalcemia side effects

A

Sluggish CNS reflexes

Constipation/lack of appetite due to depressed contractility of muscles in GI tract

17
Q

What occurs above 17 mg/dl plasma calcium level?

A

Diffuse precipitation of calcium phosphate in tissues, leading to widespread organ dysfunction and damage.

18
Q

Which hormone increases plasma calcium and maintains at 10mg%?

A

Parathyroid hormone

19
Q

Which hormone increases calcium mobilization from bone to plasma?

A

Parathyroid hormone

20
Q

Which hormone increases calcium reabsorption in renal tubules?

A

Parathyroid hormone

21
Q

Three functions of Parathyroid Hormone

A
  1. Increases plasma calcium and maintains at 10mg%
  2. Increases calcium mobilization from bone to plasma
  3. Increases calcium reabsorption in renal tubules.
22
Q

What is the hormonal form of vitamin D?

A

Calcitrol

23
Q

What hormone is produced by the kidneys in response to stimulation by the parathyroid hormone?

A

Calcitrol

24
Q

Two functions of Calcitrol

A
  1. Increases calcium absorption from intestine

2. Limits calcium excretion when blood calcium levels are low.

25
Q

Which hormone increases calcium absorption from the intestine?

A

Calcitrol

26
Q

Which hormone limits calcium excretion when blood calcium levels are low?

A

Calcitrol

27
Q

Alternate name for Thyrocalcitonin

A

Calcitonin

28
Q

Where is calcitonin produced?

A

Thyroid gland

29
Q

What hormone reverses the action of parathyroid hormone?

A

Calcitonin

30
Q

Increases in blood calcium stimulates what hormone?

A

Calcitonin

31
Q

Which hormone lowers blood calcium by inhibiting bone resorption?

A

Calcitonin

32
Q

Calcitonin _____ plasma calcium and phosphate levels

A

Decreases

33
Q

What is used in medicine to treat hypercalcemia?

A

Calcitonin

34
Q

What hormone is a minor regulator of blood calcium compared to the actions of PTH and calcitrol?

A

Calcitonin

35
Q

How is vitamin D-3 formed?

A

In the skin, when cholesterol precursor 7-dehydroxycholesterol is exposed to ultraviolet light.

36
Q

What is the primary action of vitamin D-3

A

Promote gut absorption of calcium by stimulating formation of calcium-binding protein within the intestinal epithelial cells

37
Q

What hormone has a synergistic role with parathyroid hormone?

A

Vitamin D-3

38
Q

Compared to PTH, ______ exerts a much slower regulatory effect on calcium balance.

A

Vitamin D-3