Bone Drugz N Harmony

Question 0

Cinacalcet

Answer 0

Binds calcium-sensing receptor in parathyroid to decrease PTH secretion

Question 1

Calcium

Answer 1

Add to bone go boom

Question 2

Teriparatide

Answer 2

Recombinant PTH; activates osteoblasts

Question 3

Calcitriol (aka 1, 25(OH)2-Vit D3)

Answer 3

Behaves like a hormone. Upregulates calcium binding proteins in the guts, induces osteoclast differentiation, regulates PTH secretion

Question 4

Calcitonin

Answer 4

Opposite of PTH. Reduces serum calcium: reduces osteoclastic bone resorption and reduces kidney reabsorption of calcium

Question 5

Estrogen

Answer 5

Inhibits osteoclasts

Question 6

Reloxifene

Answer 6

Selective estrogen receptor modulator

Question 7

Alendronate

Answer 7

2nd generation bisphosphonate; inhibits osteoclast-mediated bone-resorption.

Question 8

Ibandronate

Answer 8

2nd generation bisphosphonate; inhibits osteoclast-mediated bone-resorption.

Question 9

Risedronate

Answer 9

3rd generation bisphosphonate. inhibits osteoclast-mediated bone-resorption.

Question 10

Denosumab

Answer 10

Mimics the effect of osteoprotegrin; RANK-ligand antibody. Blocks osteoclast formation and activation.