Bone disorders Flashcards
1
Q
What are the common sites of fracture in osteoporosis?
A
neck of femur
vertebral body
distal radius
humeral neck
2
Q
________ are antiresorptive drugs used in osteoporosis
A
Bisphosphonates
3
Q
What are the concerns with long term use of Bisphosphonates (e.g. Alendronate)?
A
- osteonecrosis of the jaw
- oesophageal carcinoma
- atypical fractures
4
Q
What drug stimulates bone growth?
A
Teriparatide (parathyroid hormone analogue)
5
Q
How do steroids increase the risk of osteoporosis?
A
Steroids reduce:
- osteoblast activity
- calcium absorption
6
Q
What is Paget’s disease?
A
Abnormal osteoclastic activity, followed by increased osteoblastic activity, resulting in abnormal structure and risk of fracture.
7
Q
How does Paget’s disease present?
A
- Bone pain (weight bearing)
- deformities
- deafness
- compression neuropathy
8
Q
What is Osteogenesis Imperfecta? What’s the clinical picture?
A
Genetic disorder of collagen production
Children with multiple fractures
- may have blue sclera
- may affect dentition
