Bone Diseases Flashcards

1
Q

Genetic diseases of bone

A

Cheurbism
Osteopetrosis
Osteogenisis
Cleiodocrainal dysplasia

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2
Q

Developmental diseases of bone

A

Fibrous dysplasia

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3
Q

Endocrinal disorders diseases of bone

A

Hyperparathyroidism

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4
Q

Dystrophic diseases of bone

A

Paget’s disease

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5
Q

Idiopathic disease of bone

A

Idiopathic osteoscleosis
Massive osteolysis
Langerhan’s cell diseases histiocytosis X

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6
Q

Reactive diseases of bone

A

Periapical cemento osseous dysplasia
Florid cemento ossous dysplasia gigantiform cementoma
Focal cemento osseous dysplasia
Cemento ossifying fibroma
Giant cell lesion of bone

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7
Q

Inflammatory diseases of bone

A

Specific
Non specific
Osteomyelitis
- suppurative
- Sclerosing
Osteoradionecrosis

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8
Q

Neoplastic disease of bone tissue benign tumour

A

Osteoma
ossifying fibroma

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9
Q

Neoplastic diseases of bone tissues malignant tumour

A

Osteosarcoma

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10
Q

Neoplastic diseases of cartilage tissues benign tumours

A

Chondroma

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11
Q

Neoplastic diseases of cartilage tissues malignant tumours

A

Chondrosarcoma

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12
Q

Miscellaneous lesions of bone cysts

A

Odontogenic tumours
Edwin’s sarcoma
Melanitic neuroectodermal tumor of infancy
Lymphoma
Leukemia
Burkitt’s lymphoma

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13
Q

Benign hereditary condition of the maxilla & mandible

A

Cherubism familial fibrous dysplasia

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14
Q

Clinical features of Cherubism familial fibrous dysplasia

A

2 - 4 of age 7th months to 7 years , males more than females , expand bilaterally with chubby facial appearance at the angles of the mandible

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15
Q

Radiographic picture of Cherubism familial fibrous dysplasia

A

Changes earlier than clinical signs , multilocular radiolucencies and fine bony septa

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16
Q

Histopathological picture of Cherubism familial fibrous dysplasia

A

Numerous fibroblasts and multinuclieted giant cell

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17
Q

Most common inherited disease characterised by transmitted as an autosomal dominant trait

A

Osteogenesis imperfecta

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18
Q

Clinical features of Osteogenesis imperfecta

A

There is four types , at bone or dentin or sclera or ligaments & skin BLUE SCLERA , bone is fragile & osteoporotic leads to pathological fractures during delivary

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19
Q

Osteogenesis imperfecta is associated with ?

A

Dentinogenises imperfecta

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20
Q

Inherited bone disease characterised by transmitted as autosomal dominant trait

A

Cleidocranial dysplasia

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21
Q

Oral manifestation of Cleidocranial dysplasia

A

Hyper-plastic matrix high palatal arch and open bite , prognathic mandible , prolonged retention of deciduous teeth delayed eruption of permanent teeth, numerous unerapted supernumerary teeth , partial anodontia due to crowding of teeth germs , absence of cellular cementum on root of deciduous & permanent teeth and roots are short thinner than normal .

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22
Q

It is an idiopathic condition, in which normal medullary bone is gradually
replaced by an abnormal fibrous connective tissue proliferation.

A

Fibrous dysplasia

23
Q

Types of Fibrous dysplasia

A

Monostotic FD.
Polyostotic FD.

24
Q

Site of Monostotic fibrous dysplasia

A

maxilla More than mandible

25
Radiographic picture of Monostotic fibrous dysplasia
mottled appearance or ground glass appearance
26
Café au lait pigmentation Oral mucosal pigmented macules may be present Polyostotic FD. Sexual precocity Particularly females menstrual bleeding in first few months
McCune-Albright syndrome
27
Café au lait spots Polyostotic FD
Jaffe-lichtenstein's syndrome
28
Histopathology of Jaffe-lichtenstein's syndrome
Chinese script writing
29
hypersecretion of parathyroid hormone, from hyperplastic parathyroid glands.
Hyperparathyroidism(HP)
30
Aetiology of hyperparathyroidism HP
Postmenopausal women due to Decrease in estrogen level. Hlereditary. Multiple endocrine neoplasia syndrome.
31
Clinical features of hyperparathyroidism HP
Systemic manifestation. fatigue, weakness, nausea, anon thirst, depression and constipation Bones (brown's tumor) a dark reddish-brown lesion, because of the abundant hemorrhage and hemosiderin deposition within the tumor, the'lesions appear radiographically as well-demarcated unilocular multilocular radiolucencies.
32
Oral manifestation of osteitis fibrosa cystica
Brown's tumor in jaws solitary or multiple. - ground glass .
33
Histopathology of osteitis fibrosa cystica
Numerous multi nucleated giant cells osteoclast type
34
It is characterized by abnormal chronic resorption and deposition of bone, resulting in distortion and weakening of the affected bones.
Page's disease of bone(Osteitis deformans)
35
Clinical features of Paget’s disease of bone / osteitis deformans
Clinically. Age (40 years and above. Sex males > females 2.1 Race, whites >blacks Site, jaws affected in 10-15% of cases Bone pain, and the bone becomes thickened, enlargement and weakened if skull is affected there may be headache, deafness, blindness and facial paralysis due to narrowing of skull foramina, resulting in compression of vascular and neural elements
36
Oral manifestation of Paget’s disease of bone / osteitis deformans
In jaws - When maxilla is involved this will result in enlargement of the middle third of the face - In severe cases, the enlargement results in a lion - like facial deformity (leontiasis ossea) If patient is dentulous. - Wide alveolar ridge • Spacing of teeth • Lips are too small to cover enlarged jaw If teeth are absent,- • The patients are unable to wear their dentures are replaced by cotton wool appearance
37
Histological picture of Paget’s disease of bone / osteitis deformans
Formation of mosaic appearance
38
Prognosis of Paget’s disease of bone / osteitis deformans
Neurologic complications deafness or blindness caused by encroachment on cranial nerves passing through skull foramina. Malignant transformation into osteosarcoma in about 2% of paget's patients.
39
Dental complications of Paget’s disease of bone / osteitis deformans
Dental complications Hypercementosed teeth and ankylosed teeth are difficulties in extraction. Increased bleeding, dry socket and osteomyelitis may be occur after extraction. Edentulous patients change dentures from time to time due to enlargement of alveolar ridges. Pathological fracture
40
(Langerhan Cell Disease( Histiocytosis-X)
It is an idiopathic disease characterized by proliferation of histiocyte -like cells ( langerhan's cells )
41
Types of Langerhan Cell Disease( Histiocytosis-X),
Hand -Schuller-Christian's Syndrome Lettere -Siwe's Syndrome Monostatic or polyostatic eosinophilic granuloma
42
Exophthamos Diabetes insipidus. Osteolytic bone lesions are associated with lymphadenopathy, dermatitis& hepatosplenomegaly. Prognosis a child survive for about 5 years
Hand schuller christian’s syndrome
43
Osteolytic bone lesions Visceral organs involvement
Lettere siwe’s syndrome
44
Prognosis of Lettere siwe’s syndrome
it is a poor prognosis, because that is considered as a fatal disease, a child may survive just about 5 years.
45
Chronic localized form of disorder
Eosinophilic granuloma
46
Site of Eosinophilic granuloma
Intraaosseous or extraosseous conditions - visceral organs .
47
It is a benign tumor composed of mature compact or cancellous bone
Osteoma
48
Ostopathology of osteoma
Compact osteoma Cancellous osteoma
49
Complication of osteoma
Ossifying fibroma cemento ossifying fibroma cementifying fibroma
50
It is malignant mesenchymal tumour of bone
Osteosarcoma
51
Clinical features of osteosarcoma
Common in children and any age , mixed radiolucent and radiopaque lesion as well as sun rays appearance in Xray , chondrosarcoma & melanotic necroectodermal tumour infancy as a D/D
52
It is a benign mesenchymal tumour of cartilage tissues
Chondroma
53
It is a malignant mesenchymal tumour of cartilage tissues
Chondrosarcoma
54
Clinical features of chondrosarcoma
Common in children and any age , sun rays appearance in x ray ,osteosarcoma & melanotic neroectodermal tumour of infant