Bone Diseases Flashcards

1
Q

Genetic diseases of bone

A

Cheurbism
Osteopetrosis
Osteogenisis
Cleiodocrainal dysplasia

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2
Q

Developmental diseases of bone

A

Fibrous dysplasia

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3
Q

Endocrinal disorders diseases of bone

A

Hyperparathyroidism

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4
Q

Dystrophic diseases of bone

A

Paget’s disease

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5
Q

Idiopathic disease of bone

A

Idiopathic osteoscleosis
Massive osteolysis
Langerhan’s cell diseases histiocytosis X

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6
Q

Reactive diseases of bone

A

Periapical cemento osseous dysplasia
Florid cemento ossous dysplasia gigantiform cementoma
Focal cemento osseous dysplasia
Cemento ossifying fibroma
Giant cell lesion of bone

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7
Q

Inflammatory diseases of bone

A

Specific
Non specific
Osteomyelitis
- suppurative
- Sclerosing
Osteoradionecrosis

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8
Q

Neoplastic disease of bone tissue benign tumour

A

Osteoma
ossifying fibroma

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9
Q

Neoplastic diseases of bone tissues malignant tumour

A

Osteosarcoma

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10
Q

Neoplastic diseases of cartilage tissues benign tumours

A

Chondroma

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11
Q

Neoplastic diseases of cartilage tissues malignant tumours

A

Chondrosarcoma

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12
Q

Miscellaneous lesions of bone cysts

A

Odontogenic tumours
Edwin’s sarcoma
Melanitic neuroectodermal tumor of infancy
Lymphoma
Leukemia
Burkitt’s lymphoma

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13
Q

Benign hereditary condition of the maxilla & mandible

A

Cherubism familial fibrous dysplasia

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14
Q

Clinical features of Cherubism familial fibrous dysplasia

A

2 - 4 of age 7th months to 7 years , males more than females , expand bilaterally with chubby facial appearance at the angles of the mandible

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15
Q

Radiographic picture of Cherubism familial fibrous dysplasia

A

Changes earlier than clinical signs , multilocular radiolucencies and fine bony septa

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16
Q

Histopathological picture of Cherubism familial fibrous dysplasia

A

Numerous fibroblasts and multinuclieted giant cell

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17
Q

Most common inherited disease characterised by transmitted as an autosomal dominant trait

A

Osteogenesis imperfecta

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18
Q

Clinical features of Osteogenesis imperfecta

A

There is four types , at bone or dentin or sclera or ligaments & skin BLUE SCLERA , bone is fragile & osteoporotic leads to pathological fractures during delivary

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19
Q

Osteogenesis imperfecta is associated with ?

A

Dentinogenises imperfecta

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20
Q

Inherited bone disease characterised by transmitted as autosomal dominant trait

A

Cleidocranial dysplasia

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21
Q

Oral manifestation of Cleidocranial dysplasia

A

Hyper-plastic matrix high palatal arch and open bite , prognathic mandible , prolonged retention of deciduous teeth delayed eruption of permanent teeth, numerous unerapted supernumerary teeth , partial anodontia due to crowding of teeth germs , absence of cellular cementum on root of deciduous & permanent teeth and roots are short thinner than normal .

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22
Q

It is an idiopathic condition, in which normal medullary bone is gradually
replaced by an abnormal fibrous connective tissue proliferation.

A

Fibrous dysplasia

23
Q

Types of Fibrous dysplasia

A

Monostotic FD.
Polyostotic FD.

24
Q

Site of Monostotic fibrous dysplasia

A

maxilla More than mandible

25
Q

Radiographic picture of Monostotic fibrous dysplasia

A

mottled appearance or ground glass appearance

26
Q

Café au lait pigmentation
Oral mucosal pigmented macules may be present
Polyostotic FD.
Sexual precocity Particularly females menstrual bleeding in first few months

A

McCune-Albright syndrome

27
Q

Café au lait spots
Polyostotic FD

A

Jaffe-lichtenstein’s syndrome

28
Q

Histopathology of Jaffe-lichtenstein’s syndrome

A

Chinese script writing

29
Q

hypersecretion of parathyroid hormone, from hyperplastic
parathyroid glands.

A

Hyperparathyroidism(HP)

30
Q

Aetiology of hyperparathyroidism HP

A

Postmenopausal women due to Decrease in estrogen level.
Hlereditary.
Multiple endocrine neoplasia syndrome.

31
Q

Clinical features of hyperparathyroidism HP

A

Systemic manifestation. fatigue, weakness, nausea, anon
thirst, depression and constipation

Bones (brown’s tumor) a dark reddish-brown lesion, because of the
abundant hemorrhage and hemosiderin deposition within the tumor, the’lesions appear radiographically as well-demarcated unilocular
multilocular radiolucencies.

32
Q

Oral manifestation of osteitis fibrosa cystica

A

Brown’s tumor in jaws solitary or multiple. - ground glass .

33
Q

Histopathology of osteitis fibrosa cystica

A

Numerous multi nucleated giant cells osteoclast type

34
Q

It is characterized by abnormal chronic resorption and deposition of bone, resulting in distortion and weakening of the affected bones.

A

Page’s disease of bone(Osteitis deformans)

35
Q

Clinical features of Paget’s disease of bone / osteitis deformans

A

Clinically. Age (40 years and above.
Sex males > females 2.1
Race, whites >blacks
Site, jaws affected in 10-15% of cases

Bone pain, and the bone becomes thickened, enlargement and weakened

if skull is affected there may be headache, deafness, blindness and facial
paralysis due to narrowing of skull foramina, resulting in compression of
vascular and neural elements

36
Q

Oral manifestation of Paget’s disease of bone / osteitis deformans

A

In jaws - When maxilla is involved this will result in enlargement of the middle third of
the face
- In severe cases, the enlargement results in a lion - like facial deformity
(leontiasis ossea)
If patient is dentulous.
- Wide alveolar ridge
• Spacing of teeth
• Lips are too small to cover enlarged jaw
If teeth are absent,-
• The patients are unable to wear their dentures

are replaced by cotton wool appearance

37
Q

Histological picture of Paget’s disease of bone / osteitis deformans

A

Formation of mosaic appearance

38
Q

Prognosis of Paget’s disease of bone / osteitis deformans

A

Neurologic complications deafness or blindness caused by encroachment
on cranial nerves passing through skull foramina.
Malignant transformation into osteosarcoma in about 2% of paget’s
patients.

39
Q

Dental complications of Paget’s disease of bone / osteitis deformans

A

Dental complications
Hypercementosed teeth and ankylosed teeth are difficulties in extraction.
Increased bleeding, dry socket and osteomyelitis may be occur after
extraction.
Edentulous patients change dentures from time to time due to enlargement
of alveolar ridges.
Pathological fracture

40
Q

(Langerhan Cell Disease( Histiocytosis-X)

A

It is an idiopathic disease characterized by proliferation of histiocyte -like cells (
langerhan’s cells )

41
Q

Types of Langerhan Cell Disease( Histiocytosis-X),

A

Hand -Schuller-Christian’s Syndrome
Lettere -Siwe’s Syndrome
Monostatic or polyostatic eosinophilic granuloma

42
Q

Exophthamos
Diabetes insipidus.
Osteolytic bone lesions are associated with lymphadenopathy, dermatitis&
hepatosplenomegaly.
Prognosis a child survive for about 5 years

A

Hand schuller christian’s syndrome

43
Q

Osteolytic bone lesions
Visceral organs involvement

A

Lettere siwe’s syndrome

44
Q

Prognosis of Lettere siwe’s syndrome

A

it is a poor prognosis, because that is considered as a fatal
disease, a child may survive just about 5 years.

45
Q

Chronic localized form of disorder

A

Eosinophilic granuloma

46
Q

Site of Eosinophilic granuloma

A

Intraaosseous or extraosseous conditions - visceral organs .

47
Q

It is a benign tumor composed of mature compact or cancellous bone

A

Osteoma

48
Q

Ostopathology of osteoma

A

Compact osteoma
Cancellous osteoma

49
Q

Complication of osteoma

A

Ossifying fibroma cemento ossifying fibroma cementifying fibroma

50
Q

It is malignant mesenchymal tumour of bone

A

Osteosarcoma

51
Q

Clinical features of osteosarcoma

A

Common in children and any age , mixed radiolucent and radiopaque lesion as well as sun rays appearance in Xray , chondrosarcoma & melanotic necroectodermal tumour infancy as a D/D

52
Q

It is a benign mesenchymal tumour of cartilage tissues

A

Chondroma

53
Q

It is a malignant mesenchymal tumour of cartilage tissues

A

Chondrosarcoma

54
Q

Clinical features of chondrosarcoma

A

Common in children and any age , sun rays appearance in x ray ,osteosarcoma & melanotic neroectodermal tumour of infant