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Basic science > Bone > Flashcards

Bone Flashcards

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Biology 101 flashcards
1
Q

What does sclerostin do

A

Inhibits osteoblasts
BLOCKS Wnt/beta catenin pathway
DECREASES bone mass

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2
Q

Where does sclerostin come from

A

osteocytes

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3
Q

Transcription factors assoc w/ bone formation

A

RUNX2, beta catenin, Osx

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4
Q

What do osteoblasts produce

A

RANKL, osteoprotegrin

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5
Q

Receptors on osteoblasts

A

PTH

1,25 Vit D

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6
Q

Receptors on osteoclasts

A

RANK
calcitonin
M-CSF
Integrin

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7
Q

Inhibitors of osteoclasts

A 
Calcitonin
IL-10
OPG
Estrogen
TGF-beta
Denosumab
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8
Q

Organic composition of bone

A 
Collagen
Proteoglycans
Osteocalcin
Osteonectin
Osteopontin
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9
Q

Composition of proteoglycans

A

HA backbone

GAGs (keratin sulfate, chondroitin sulfate)

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10
Q

Physis zones

A 
Epiphysis
Resting/Reserve
Proliferative
Hypertrophy (Maturation, Degenerative, Provisional calcification)
Primary spongiosa (metaphysis)
Secondary spongiosa
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11
Q

Reserve zone of physis disorders

A

Gaucher’s
Kneist
Diastrophic dysplasia
Pseudoachondroplasia

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12
Q

Proliferative zone of physis disorders

A

Achondroplasia
MHE
Gigantism

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13
Q

Hypertrophic zone of physis disorders

A 
SCFE
Rickets
Enchondromas
Schmids
SH1 fx
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Basic science (7 decks)

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