Body Response (SELF STUDY) to Tissue Damage: Chronic and Granulomatous Inflammation

Question 1

Chronic inflammation

Answer 1

when a damaging stimulus persists, complete healing cannot occur, chronic inflammatio ensues

Question 2

Causes of chronic inflammation

Answer 2

damaging stimulus not amenable to eradication or neutralisation
bacteria persists as they are distanced from neutrophils, antibiotics
bacteria persist as they are resistant to neutrophil phagocytosis

Question 3

signs of chronic inflammation

Answer 3

scarring

absence of cardinal signs such as redness, swelling, pain, and increased temperature

Question 4

Granulation inflammation

Answer 4

form of chronic inflammation where neutrophuls are ineffective so macrophages are involved early
aggregations of macrophages around the damaging agent associated with surrounding lymphocytes and fibroblasts form a granuloma

Question 5

Causes of granulation inflammation

Answer 5

low pathogenicity organisms which excite a typeIV immune response
organic/inorganic foreign material
some fungi
sarcoidosis

Question 6

Example of granulomatous inflammation

Answer 6

tuberculosis

Question 7

Why is TB an example of granulomatous inflammation

Answer 7

causative organism is resistant to destruction by neutrophils
can be phagocytosed and immobilised by macrophages - type IV response
stalemate