Body Fluids Flashcards
What are the components of blood?
Fluid matrix, plasma and formed elements (erythrocytes, leucocytes and thrombocytes)
Describe the morphology of plasma
It is a straw coloured, viscous fluid and constitutes about 55%of blood
What are the major proteins in plasma?
Fibrinogen (clotting), globulins (defence mechanism) and albumins (osmotic balance).
What are plasma made of?
90 - 92% water and 6-8% protein and minerals such as Na, Ca, HCO3, Cl etc.
What is the healthy composition of RBC in blood?
5 -5.5 million RBC/mm³
Write the morphological features of RBC .
It is red in colour, iron containing and has haemoglobin. It is devoid of nucleus and biconcave in shape.
What is the healthy composition of haemoglobin in blood?
12 - 16 gms in 100ml of blood
Where is RBC formed and destroyed?
Formed - red bone marrow, Destroyed - spleen
Write the morphological features of WBC.
Colourless (no haemoglobin), nucleated, present in 6000 - 8000 per mm³ of blood.
What are the two categories of WBC ?
Granulocytes and Agarnulocytes
What are the types of granulocytes and their features?
Neutrophils (60 - 65%) - phagocytic cells.
Basophils (0.5 - 1%) - secrete histamine, serotonin and heparin; involved in inflammation.
Eosinophils (2 - 3%) - resists infection and is associated with allergic reaction.
What are the types of Agarnulocytes and their features?
Lymphocytes (20-25) - two types_b and t forms, both are responsible for immune response.
Monocytes (6-8) - phagocytic cells
How are thrombocytes produced?
Cell fragments are produced by megakaryocytes (special cells in bone marrow).
What is the composition of platelets in blood?
1,50,000 - 3,00,000/mm³
What is the role of platelets?
Releases substances involved in coagulation and clotting of blood.
Reduction in it will cause clotting disorder.
How is clotting done?
Thrombokinase gets converted into prothrombin and further into thrombin. Thrombin leads to the activation of fibrinogen and the formation of scum.
What are the two methods for grouping blood?
ABO and Rh
What are antigens and anti-bodies?
Antigen - chemical that induces immune system
Anti bodies - proteins produced in response to antigens
What will happen if blood is mismatched during blood transfusion?
It will lead to the problem of clumping (destruction of RBC).
Write the donors compatibility to all the 4 groups.
A :
Antibodies - anti b
Antigen - a
Donors group - a,o
B:
Antibodies - anti a
Antigen - b
Donors group - b,o
AB:
Antibodies - nil
Antigen - a,b
Donors group - a,b,ab,o
O:
Antibodies - anti a and b
Antigen - nil
Donors group - o
Name the universal donor and universal recipient.
Universal donor - O
Universal recipient - AB
What are Rh antigens?
Observed on the surface of the RBC of nearly 80% of humans. (Present in Rhesus monkey).
What is erythroblastosis foetalis?
A special case when the Rh +ve blood of the foetus enters the Rh -ve blood of the mother. The mother’s blood will start producing Rh antibodies which will destroy the foetus blood leading to anaemia or jaundice.
Prevention: administration of anti Rh antibodies into the mother’s blood after the delivery of the 1st child.
What are fibrin?
A network of threads in which dead and damaged formed elements of blood are trapped.
How are thrombokinases formed?
They are formed by a series of Linked enzymic reactions (cascade process) involving factors present in plasma in an inactive state.
Which ions play an important role in clotting ?
Calcium ions
What is lymph ?
Fluid containing water with some water soluble substances moves out into the space between cells of tissues.
What occurs in the lymph fluid?
Exchange of nutrients, gas etc. between blood and cells.