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Haematology > Blood Product Transfusion Complications > Flashcards

Blood Product Transfusion Complications Flashcards

1
Q

What causes non haemolytic febrile reaction

A

Antibodies react w/ white cell fragments in blood products + cytokines that leaked from blood cell during storage

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2
Q

How does non haemolytic febrile reaction present (2)

A

Fever

Chills

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3
Q

What products cause non haemolytic febrile reaction (2)

A

Red cell transfusion

Platelet transfusion

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4
Q

Management of non haemolytic febrile reaction (3)

A

Stop or slow transfusion
Paracetamol
Monitor

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5
Q

What causes a minor allergic reaction

A

Foreign plasma proteins

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6
Q

Symptoms of minor allergic reaction (2)

A

Pruritus

Urticaria

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7
Q

Treatment of minor allergic reaction (3)

A

Temporarily stop the transfusion
Antihistamine
Monitor

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8
Q

Cause of anaphylaxis

A

Patients w/ IgA deficiency who have high anti IgA antibodies

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9
Q

Symptoms of anaphylaxis (4)

A

Hypotension
Dyspnoea
Wheezing
Angioedema

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10
Q

Treatment of anaphylaxis (3)

A

Stop the transfusion
IM adrenaline
ABC support (oxygen, fluids)

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11
Q

Cause of acute haemolytic reaction

A

ABO incompatible blood e.g. secondary to human error

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12
Q

Symptoms of acute haemolytic reaction (3)

A

Fever
Abdo pain
Hypotension

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13
Q

Treatment of acute haemolytic reaction (3)

A

Stop transfusion
Confirm diagnosis - patient identity, direct Coombs test, cross match
Supportive care - fluids

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14
Q

TACO cause (2)

A

Excessive rate of transfusion

Pre existing HF

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15
Q

TACO symptoms (2)

A

Pulmonary oedema

Hypertension

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16
Q

TACO treatment (2)

A

Slow or stop transfusion

Consider IV loop diuretic

17
Q

TRALI symptoms (4)

A

Hypoxia
Pulmonary infiltrates on CXR
Fever
Hypotension

18
Q

TRALI treatment (2)

A

Stop transfusion

Supportive care

19
Q

How long till symptoms acute haemolytic

A

Mins after transfusion begins

20
Q

Complications of acute haemolytic (2)

A

DIC

Renal failure

21
Q

When does TRALI happen

A

Within 6 hrs

Haematology (6 decks)

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