Blood Physiology Flashcards
connective tissue that consists of cells & cell fragments surrounded by a liquid matrix
Blood
blood contributes ________% of the body weight
8
liquid matrix in the blood
plasma
component of blood that is 45% the total
formed elements
RBC is how many % of the formed elements of blood?
95
WBC is how many % of the formed elements of blood?
4-5
Platelets are how many % of the formed elements of blood?
<1
Other component of blood consisting of the remaining 55%
Plasma
H2O is ___ % of plasma
91
Proteins are ____ % of plasma
7%
most abundant plasma protein
albumin
percentage of albumin in plasma
58%
function of albumin
protein transport
percentage of globulin in plasma
38%
percentage of fibrinogen in plasma
48%
function of fibrinogen
clotting factor
Normal RBC count in males
5.2 - 6.5 million/mm3
Normal RBC count in females
4.5 - 5.5 million/mm3
Normal Hgb count in males
13 - 18 g/dL
Average normal Hgb count in males
16 g/dL
Normal Hgb count in females
12 - 16 g/dL
Average normal Hgb count in females
14 g/dL
term used to identify percentage of RBC in the blood
hematocrit
Normal Hct value in males
42 - 52%
Normal Hct value in females
37 - 47%
Hallmark for inflammation
erythrocyte sedimentation rate
Normal ESR value in males
< 15 mm/h
Normal ESR value in females
<25 mm/h
Normal WBC count
5,000 - 10,000 /mm3
Normal platelet count
150,000 - 350,000 /mm3
Normal bleeding time
1 - 6 minutes
Normal clotting time
6 - 10 minutes
Hct value that would render contraindication to exercise
<27%
Hgb value that would render contraindication to exercise
<8 g/dL
WBC count that would render contraindication to exercise
<5,000 /mm3
Platelet count that would render contraindication to exercise
<20,000 /mm3
type of exercise done for platelet count within 20,000-50,000
light exercise
function of RBC
transport oxygen
lifespan of RBC
120 days
characteristics of RBC
biconcave disc, (-) nucleus, (+) Hgb, pliable
function of Hgb
the actual oxygen carrier
All formed elements in the blood are derived from
pluripotential hematopoietic stem cell
other term for PHSC
hemocytoblast
process of RBC formation
Erythropoiesis
hormone that stimulates production of RBC
erythropoietin
origin of erythropoietin (include %)
kidney (90%), liver (10%)
1st stage of RBC formation
(PoBRE)
proerythroblast
2nd stage of RBC formation;
1st generation cell in RGB formation where the cell starts to acquire Hgb
(PoBRE)
basophil erythroblast
3rd stage of RBC formation:
- (+) ejection of nucleus
(PoBRE)
reticulocytes
4th stage of RBC formation
(PoBRE)
Erythrocyte
producer of RBC during 1st trimester
yolk sac
producers of RBC during 2nd trimester
liver, thymus, spleen, lymph nodes
produces of RBC during 3rd trimester until p birth
bone marrow
factors that increase RBC formation
__Hint__: BATCH
Bone marrow disease
Altitude is higher
Tissue hypoxia
Circulatory disease
Hemorrhage
Vitamin that causes pernicius anemia if absent.
Vit B12
other name for vit B12
cyanocobalamin
also known as Vit B9
folic acid
Vit B12 and Vit B9 are best absorbed where?
ileum
vitamin responsible for Hgb synthesis
iron
Fe is best absorbed in _______
duodenum