BLOOD LECTURE 3: MYELOID & LYMPHOID NEOPLASMS

Question 1

What are the 2 dangers of unregulated clonal proliferation of hematopoietic stem cells?

Answer 1

1. Malignant cells fail to differentiate fully/function properly
2. Tumour cells crowd out normal hematopoietic tissue

Question 2

Myeloid neoplasms include malignancies of which cells?

Answer 2

1. Lymphoid stem cells
2. NK cells
3. T cells
4. B cells

Question 3

Lymphoid neoplasms include malignancies of which cells?

Answer 3

1. Myeloid stem cells
2. Neutrophils
3. Monocytes
4. RBCs
5. Megakaryocytes

Question 4

What is the term for circulating tumours that primarily involve blood and bone marrow?

Answer 4

Leukemia

Question 5

What is the term for solid tumours that tend to localize in lymph tissues?

Answer 5

Lymphoma

Question 6

Which type of leukemias are associated with blast cells, have an abrupt onset and progress rapidly?

Answer 6

Acute leukemias

Question 7

Which type of leukemias are associated with more mature cells, are slow to develop, and often discovered by accident during routine blood tests?

Answer 7

Chronic leukemias

Question 8

Which leukemia involves translocation between chromosome 9 and 22 which forms a new fusion gene
(bcr-abl/Philadelphia chromosome) that triggers cell proliferation and reduces apoptosis?

Answer 8

Chronic myeloid leukemia

Question 9

What are the 3 phases of CML?

Answer 9

1. Chronic phase: asymptomatic
2. Accelerated phase: proliferation
3. Blast crisis: acute symptoms