Blood Group System Flashcards
1
Q
ISBT #007
A
The Lewis system (Le)
2
Q
The only major system not produced by RBCs. Intrinsic to GIT
A
Lewis
3
Q
Ags are on type 1 glycosphingolipids
A
Lewis
4
Q
Gene at chromosome 19 and codes for Gucosyltransferase 3
A
Lewis
5
Q
Le (a+ b+) possible in
A
Asians
6
Q
lele / Le (a- b-) / (Le^null) possible in
A
Blacks
7
Q
Associated with Helicobacter pylori
A
Le^b
8
Q
ISBT #002; Chromosome 4
A
MNS system
9
Q
• On glycophorin A
• amino acid #1 - serine
• amino acid # 5 - Glycine
A
M antigen
10
Q
• On glycophorin A
• amino acid #1 - Leucine
• amino acid # 5 - Glutamic acid
A
N antigen
11
Q
On glycophorin B
Amino acid #29 - Methionine
A
S antigen
12
Q
On glycophorin B
Amino acid #29 - Threonine
A
s antigen
13
Q
Reaction enhanced at pH 6.5 (acidic)
Seen in multiparous women
A
Anti-M
14
Q
Reaction enhanced at alkaline pH
Seen in RENAL DIALYSIS patient where machine is sterilized with formaldehyde
A
Anti-N
15
Q
ISBT # 003
A
P1PK
16
Q
Antigen that deteriorates rapidly upon storage. False nega in old specimen
A
P1 antigen
17
Q
Neutralized by hydatid cysts fluid from E. Granulosus
A
Anti-P1
18
Q
Found in fascioliasis
A
Anti-P1
19
Q
Biphasic hemolysin
A
Autoanti-P
20
Q
_____ receptor for parvovirus19
_____ receptor for SHIGA TOXIN; cause HUS
_____ receptor for P-fambriated uropathogenic E. coli
A
P antigen
P^k antigen
P system antigens
21
Q
_____ hydatid cysts and other parasitic infection
_____ spontaneous abortions in Early pregnancy
_____ PCH
A
Anti-P1
Anti-Tja
Autoanti-P
22
Q
ISBT#027
A
I (individual) system
23
Q
Associated with HEMPAS or Chronic Dyserythropoietic Anemia II
A
I system
24
Q
HEMPAS
A
Hereditary Erythroblastic Multinuclearity with Positive Acidified Serum test
25
Most common agglutinin in patient with hemolytic anemia
Pathogenic Autoanti-I / Anti-I
26
Causes acrocyanosis
Anti-I / pathogenic Autoanti-I
27
Associated with congenital cataracts in Asians
Adult i
28
Associated with:
IM
EBV infxn
Alcoholic Cirrhosis
Anti-i
29
ISBT#006; gene at chromosome 7
Kell
30
First blood group to be discovered after antiglobulin testing
Kell
31
ISBT#009; Chromosome 18
KIDD System
32
Antigens of Kidd blood group
- Jk (a+b-)
- Jk (a+b+)
- Jk (a-b+)
- Jk (a-b-)
33
Antibodies of Kidd, Jk
- Anti-Jk^a
- Anti-Jk^b
- Anti-Jk3
34
***Allen and colleagues (1951) reported finding antibody in the serum of Mrs. Kidd, whose infant (John Kidd) had HDFN***
35
**Notorious** in blood bank;
Anti-Jk^a
Anti-Jk^b
36
Can cause ***severe immediate and delayed fatal HTR *** and ***mild HDFN***
Anti-Jk3
37
Antihypertensive drugs that is associated with ***Drug induced HTR***
Aldomet and Methyldopa
38
ISBT #005; CHROMOSOME 19q
Lutheran System **Lu**
39
Jk(a+b-) seen in
Blacks
40
Jk(a-b+) and Jk (a+b+) seen in
Asians and Whites
41
Jk(a-b-) seen in
0.9% Polynesians
- Filipino
- Indonesians
- Japanese
- Chinese
42
Lutheran Antigens
- Lu^a
- Lu^b
- Lu3
43
Lutheran antibodies
- anti-Lu^a
- anti-ALu^b
- Anti-Lu^3
44
Found in patient with SLE, RT reacting IgM and is naturally occurring
**Clinically insignificant**
Anti-Lu^a
45
Associated with **shortened survival of transfused cells** and **post transfusion jaundice**(not severe)
Anti-Lu^b
46
ISBT #010; Chromosome 17q
Diego system, *Di*
47
Found in tissues like as **brain, hepatocytes, lungs, pancreas, placenta, and skeletal muscle**
Lu^a, Lu^b, and Lu3
48
Located on **BAND-3 / ANION EXCHANGE-1(AE-1)** or **SLC4A1**
Diego antigens
SLC4A1 - *solute carrier family-4 anion exchanger, member 1*
49
Defects in AE-1 CAUSES
Congenital **Acanthocytosis**
Hereditary **Spherocytosis**
Southeast Asian **Ovalocytosis**
50
Diego Antibodies
Anti-Di^a
Anti-Di^b
Anti-Wr^a
Anti-Wr^b
51
1. Anti-Di^a and -Di^b causes _______________
2. Anti-Wr^a causes _______________
3. Anti-Wr^b is *relatively* ________________
1. HTRs and HDFN
2. **Severe** HTR
3. common in the serum of the patients with WAIHA
52
ISBT #011; Chromosome 7q
Cartwright, *Yt*
53
Located on ***Acetylcholine Esterase***
Cartwright antigen
*On GPI, GLYCOSYLPHOSPHATIDYLINOSITOL - linked RBC glycoprotein*
54
UYt antigens
- Yt^a
- Yt^b
55
Yt antibodies
- Anti-Yt^a
- Anti-Yt^b
*Ab:IgG stimulated by**pregnancy and transfusion***
56
ISBT #12; Chromosome X
Xg system
57
ENHANCED by enzymes
**KALIPR**
- Kidd
- ABO
- Lewis
- I
- P1
- Rh
58
UUNAFFECTED by enzyme
**SKUL**
- Scianna
- Kell
- U
- Lutheran
59
DESTROYED by enzymes
**DaMMn eX**
- Duffy
- MNS
- Xg^a
- minor
- JMH
- Ch/Rg
- Pr
60
Mixed filled reaction
- Sd^a
- Lutheran
61
Absent in PNH III
- Dombrock
- Cartwright
- Cromer
- JMH
62
Antigens in
- saliva
- urine
- meconium
**Sd^a**
63
Soluble form of *Tamm-horsefall protein*
UROMODULIN
64
Antibody neutralized by urine
*anti-Sd^a*
65
BennettGoodspeed Antigens
A.k.a. HUMAN LEUKOCYTE ANTIGENS
66
Bg^a..........
Bg^b..........
Bg^c...........
Bg^a **HLA B7
Bg^b **HLA B17
Bg^c **HLA A28
67
ISBT "022; CHROMOSOME 1q
**Knops**
68
Located on Complement receptor 1 **(CR1)** or **CD35**
**Knops**
69
Knops decreased in
- **SLE
- Coronary Artery Disease (CAD)**
70
Phenotype of Knops null
HELGESON
71
ISBT #023; Chromosome 11p
INDIAN
72
In^a and In^b located in
CD44
73
Chromosome 19p; ISBT #024
Ok system (Mr. Kabutso)
74
Ok Antigens carried on
**CD147**
75
Chromosome 11p; ISBT #025
Raph system
76
Raph antigen
MER-2
77
Raph located on
CD151
78
Chromosome 15q; ISBT #026
John Milton Hagen JMH
79
JMH antigens located on:
CDW108
SEMAPHORIN 7A
80
Newest blood group
ISBT #030
RHAG
81
Chromosome 6p
82
Carbohydrate antigens
**LIP**
Lewis
I
P
83
Poorly developed at birth
**LLP**
- Lewis
- Lutheran
- P1
84
Well developed at birth
**DaMaK Ka**
Duffy
MNSs
Kell
Kidd
85
In Vito hemolysis
Anti-Le^a/ Anti-Le^b
Anti-Tja
Anti-Vel
86
IgM antibodies
**LIPBAHMN**
LEWIS
I
P
B
A
M
N
87
IgG antibodies
Rh
Kidd
Kell
Duffy
Lutheran
MNSs
88
Decreased Ab in pregnancy (post-partum)
Le
89
Neutralization
Anti-I/I : human breast milk
Anti-Sd^a Antibody : Guinea pig urine
Anti Ch/Rg : plasma/serum
Anti p1 Ab : hydatid cysts fluid, turtle dove's egg whites, pigeon dropping
90
Made by the Cromer null Inab phenotype
Anti-IFC
91
Chromosome 1q; ISBT #021
Cromer
92
Cromer antigens carried on
**DAF** *DK accelerating Factor
A.k.a. CD55
93
Chromosome 2q; ISBT #020
Gerbich system
94
Reacts with anti-AB and anti-B
B
95
Mix filled reaction with anti-AB and anti-B
Most frequent B subtype
B3
96
Weak reaction with anti-AB and anti-B
Bx
97
No/weak reaction with anti-AB and anti-B
Converted to B if incubated with **Uracil diphosphate**
Bm
98
No reaction with anti-AB and anti-B
Extremely rare phenotype
B el
99
Anti-A1 lectin
Dolichos biflorus
100
Anti-B lectin
Bandeiraea simplicifolia
Gniffonia simplicifolia
101
Anti-H lectin
Ulex europaeus
102
Anti-N lectin
Vicia graminea
103
Anti-M lectin
Iberis amara
104
Anti-T, Th lectin
Arachis hypogaea
105
Anti-Tn lectin
Salvia sclarea
106
Positive control in antisera QC
Ensures the **Reactivity**of the antisera
107
Negative control in antisera QC
Ensures the **Specificity** of the antisera
108
Higher frequency in females than males
Xg
109
Associated with**CD99**
A.KA. **12E7 & MIC 2
Xg
110
ISBT #013; Chromosome 1
Scianna
111
Expressed on RBC adhesion protein called **ERMAP**
Scianna
*Erythrocyte Membrane Associated Protein*
112
1% in northern Europeans but Higher in **Mennonite** population.
SC2
113
Chromosome 12; ISBT #014
Dombrock
114
Carried on ART-4
Dombrock
*Mono-ADP Ribosylteansferase-4*
115
Associated with **R**en**al** **d**isease
Raph antibody
116
X-linked; located on the short arm of X chromosome
Xg
117
Male- 66%
Female - 89%
Xg Ag
118
Xg antibody
Anti - Xga
119
ISBT#015; Chromosome 7p
Colton
120
Antigens located on **Aquaporin-1**
Colton Ag
121
Colton Antibodies
Anti-Co^a
Anti-Co^b
122
ISBT #017; Chromosome 6p
Chido/Rogers
123
Found on **C4** complement
Ch/Rg Ag
124
Nebulous Ag
Ch/Rg Ag
125
Not intrinsic to RBCmembrane
Lewis and Ch/Rg Ags
