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Blood Bank > Blood Components (Plasma Products and Derivatives) > Flashcards

Blood Components (Plasma Products and Derivatives) Flashcards

1
Q

Plasma from the whole blood donation can be
manufactured into a variety of components

A

Fresh Frozen Plasma

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2
Q

Component variety of FFP: (2)

A
  1. Frozen
  2. Cryoprecipitate
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3
Q

How is FFP prepared:

A

prepared by removing plasma from a whole blood and frozen within 8 hours of collection

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4
Q

Indication of FFP: (6)

A
  1. Transfused to justify for the replacement of plasma protein when specific concentrates are not available
  2. Treatment of multiple coagulation factor deficiencies.
  3. Massive Transfusion
  4. Trauma
  5. Liver Disease
  6. DIC
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5
Q

Multiple coagulation factor
deficiencies that FFP is used for: (6)

A
  1. Bleeding
  2. Unavailability of Factor VIII and VIII concentrate
  3. Abnormal Coagulation Assay
  4. Anti-thrombin pre -treatment
  5. Thrombotic Thrombocytopenic Purpura
  6. Hemolytic Uremic Syndrome
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6
Q

Contraindication of FFP:

A

Not appropriate as volume expander

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7
Q

Shelf life of FFP:

Frozen:
Thawed:

A

Frozen: 1 year or 7 years

Thawed: 37°C water bath for 24 hours

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8
Q

Storage temp of FFP:

Frozen:
Thawed:

A

Frozen: -18°C or colder

Thawed: 30-37°C water bath followed by 1-6°C storage after thawing.

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9
Q

How long must thawed FFP be transfused before it no longer becomes viable?

A

24 hours

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10
Q

Contents of FFP

A

All coagulation factors including 400 mg of fibrinogen

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11
Q

Its indication is for treatment of stable clotting factor deficiencies

A

Single Donor Plasma

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12
Q

Shelf Life of Single Donor Plasma:

Liquid:
Frozen:

A

Liquid: 5 days beyond whole blood expiration
Frozen: 5 years

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13
Q

Storage Temp of Single Donor Plasma:

Liquid:
Frozen:

A

Liquid: 1-6°C
Frozen: -18°C or colder

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14
Q

Plasma component that is prepared from Fresh Frozen Plasma that is thawed at 30-37°C and stored at 1-6°C

A

CRYOPRECIPITATED ANTIHEMOPHILIC FACTOR

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15
Q

Indications of CRYOPRECIPITATED ANTIHEMOPHILIC FACTOR:

A
  1. Hemophilia A
  2. von Willebrand’s disease
  3. Fibrinogen deficiency
  4. Factor XIII deficiency (Stable clotting factor)
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16
Q

Shelf life of Single Donor Plasma:

Frozen:
Thawed:
Pooled:

A

Frozen: 1 year
Thawed: 6 hours
Pooled: 4 hours

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17
Q

Storage Temp of Single Donor Plasma

Frozen:
Thawed:

A

Frozen: -18°C or colder
Thawed: Room temp (20-24°C)

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18
Q

Contents of Single Donor Plasma and its percentage: (4)

A

Factor VIII:C - 80-150 IU
Factor VIII:vWF – 40-70%
Fibrinogen – 150-250 mg
Factor XIII – 20-30%

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19
Q

Limited to patients that undergo chemotherapy that is prone to neutropenia

A

GRANULOCYTE CONCENTRATE

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20
Q

How is granulocyte concentrate prepared?

A

Prepared via apheresis as it provides high yield product compared when it is prepared via whole blood.

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21
Q

Therapeutic dose of granulocyte concentrate:

A

1.0 x1010 per day

22
Q

Indications of granulocyte concentrate:

A

To correct severe neutropenia

Fever unresponsive to antibiotic/antifungal therapy

Myeloid hypoplasia of the bone marrow

23
Q

Shelf life of granulocyte concentrate:

A

24 hours

24
Q

Storage temp of granulocyte concentrate:

A

20-24°C without the need of agitation

25
Q

Contents of granulocyte concentrate:

A

≥ 1.0 x 1010 WBC

26
Q

Concentrates of plasma proteins that are prepared from pools of plasma

A

Plasma Derivatives

27
Q

Given to patients with hemophilia A in relation to FVIII deficiency

A

FACTOR VIII CONCENTRATE

28
Q

Shelf life of factors VIII and IX concentrate:

A

Varies on the expiration date on the vial

29
Q

Storage temp of factors VIII and IX

A

1-6°C (Lyophilized)

30
Q

Indication of:

Factor VIII:
Factor IX:

A

Factor VIII: Hemophilia A
Factor IX: Hemophilia B

31
Q

Primarily IgG antibody. Used for patients with Congenital
Hypogammaglobulinemia

A

Immune Serum Globulin

32
Q

Shelf life of Immune Serum Globulin

A

Depend on the route of administration
o Intramuscular: 3 years
o Intravenous: 1 year

33
Q

Indication of Immune Serum Globulin:

A
  1. Prophylactic treatment for those exposed to
    hepatitis, measles, and chicken pox.
  2. Hypogammaglobulinemia
34
Q

Given to those requiring plasma volume expansion

A

Normal Serum Albumin

35
Q

Shelf life and storage of normal serum albumin

A

3 years at 20-24°C
5 years at 1-6°C

36
Q

Content of Normal Serum Albumin:

A

96% Albumin
4% Globulin

37
Q

Prepared the same as how NSA is prepared, however, it does not have as much as high albumin content.

A

Plasma Protein Fraction

38
Q

Indication of PPF:

A

Plasma Volume Expansion

39
Q

Shelf life and storage of Plasma Protein Fraction:

A

3 years at 20-24°C
5 years at 1-6°C

40
Q

Contents of Plasma Protein Fraction:

A

85% Albumin
15-20% Globulin

41
Q

Required Dose of Irradiation of Irradiated Blood:

A

o 25(gy) in the middle of the canister
o 15 (gy) – lowest or minimum dose

42
Q

Importance of Irradiating Blood

A

Indicated by AABB Standards, it is important in irradiating blood components if:
o The donor unit is from a blood relative of the recipient
o The donor unit’s HLA match the patient
 Note: T-lymphocyte in the blood can cause TA-GVDH

43
Q

Given to females that are Rh (-)ve that are pregnant with Rh (+)ve child

A

RhoGAM

44
Q

Shelf life and storage of RhoGAM

A

3 years at 1-6°C

45
Q

Content of RhoGam:

Full Dose
Mini Dose

A

Full dose: 300ug Anti-D
Mini dose: 50ug Anti-D

46
Q

Indication of RhoGAM

A

Prevention of Rho (D) immunization

47
Q

Provide a safe alternative with regards to disease transmission because they are already sterilized and contain no human plasma

A

Synthetic Volume Expanders

48
Q

Examples of Synthetic Volume Expanders: (5)

A

NSS
Electrolyte Solution
Hydroxyethyl starch (HES)
Ringer’s lactate
Dextran

49
Q

Crystalloid vs. Colloids

Crystalloid

Best Example:
IV Retention:
Peripheral Edema:
Pulmonary Edema
Excretion:
Allergic Reactions:
Cost

A

Best Example: Ringer’s lactate
IV Retention: Poor
Peripheral Edema: Common
Pulmonary Edema: Possible
Excretion: Easily excreted
Allergic Reactions: Absent
Cost: Cheaper/inexpensive

50
Q

Crystalloid vs. Colloids

Colloid

Best Example:
IV Retention:
Peripheral Edema:
Pulmonary Edema
Excretion:
Allergic Reactions:
Cost

A

Best Example: Dextran
IV Retention: Good
Peripheral Edema: Possible
Pulmonary Edema: Possible
Excretion: Not easily excreted
Allergic Reactions: Rare
Cost: Expensive

Blood Bank (7 decks)

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