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ANGELO FLASHCARDS > Blood Component Preparation and Transfusion Therapy > Flashcards

Blood Component Preparation and Transfusion Therapy Flashcards

1
Q

Blood collected from a donor before separation into its components

A

Whole Blood

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2
Q

Parts of whole blood that can be separated by centrifugation consists of

A

RBC
Plasma
Cryoprecipitated Antihemophilic Factor
Platelets

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3
Q

Treatment of a disease or condition by the use of blood or blood derivatives

A

Hemotheraphy

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4
Q

Collection of blood in a sterile blood container

A

Closed System

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5
Q

Collection or exposure to air through an open port that would shorten the expiration because of potential bacterial contamination

A

Open System

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6
Q

What solution works to prevent clotting and extend the sstorage of Red Blood Cells

A

Anticoagulant Preservative Solution

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7
Q

The volume of anticoagulant preservative solution in the primary collection bag is ___mL or _____ mL

A

63 mL or 70 mL

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8
Q

The standard whole blood collection volume is _____ mL for blood collected in a bag containing ____ mL of anticoagulant or ______ mL for the larger volume bag containing _____ mL of anticoagulant preservative

A

450+-45
63mL
500+_50
70 mL

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9
Q

Reducing the anticoagulant may be necessary if a unit of blood is collected from an individual weighing less than ____lb

A

110 lb

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10
Q

Heavy Spin for PRBC, Platelet concentrate

A

5000 g for 5 mintues

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11
Q

Heavy Spin for Cryo, Cell free plasma

A

5000 G FOR 7 minutes

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12
Q

Heavy Spin for platelet - rich plasma

A

2000 g for 3 minutes

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13
Q

Binds calcium, prevents coagulation by chelating calcium, alsoprotects red cell membrane

A

Citrate

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14
Q

Provides energy to RBC, supports ATP Generation by glycolytic pathway

A

Dextrose

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15
Q

To lower the pH, Prevents caramelization

A

Citric Acid

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16
Q

Increase ATP, prevents excessive decrease in pH

A

Phosphate Buffer

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17
Q

Improves survival of RBC, Acts as substrate for red cell ATP synthesis

A

Adenine

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18
Q

In Mannitol, ____ acts as membrane stabilizer

A

Osmotic Diuretic

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19
Q

Days forCPD

A

21

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20
Q

Days for CP2D

A

21

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21
Q

Days for CPDA 1

A

35

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22
Q

Days for AS-1 (Adsol)

A

42

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23
Q

Days for AS-3 (Optisol)

A

42

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24
Q

It is used in some blood centers to regenerate ATP and 2,3 DGP

A

Rejuvination Solutions

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25
Q

In rejuvenation solution, red cells stored in the liquid state for fewer than ___ days after their outdate are rejuvanted for ___ to ___ hours, at ___ deg C with the solution

A

3 DAYS
1 - 4HOURS
37 Deg C

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26
Q

What is PIPA in rejuvination solution

A

Phosphate, Inosine, Pyruvate, Adenine

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26
Q

Only FDA approved rejuvenation solution in US

A

Rejuvesol

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26
Q

What is PIGPA in rejuvination solution

A

Phosphate, Inosine, Gluose, Pyruvate, Adenine

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27
Q

Whole blood is the unmodified component drawn from a donor, which consists of ___, ___, ___, and ____ with anticoagulant preservative solution

A

Erythrocyte, Leukocyte, and Plasma Proteins

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28
Q

Wholeb lood is stored in a monitored refrigerator at ___ - ____ Deg C for ___ days if collected in CPD or for ___ days if collected in CPDA 1

A

1-6 Deg C
21 days
35 days

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29
Q

Storage for WHOLE BLOOD

A

1-6C

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30
Q

Transport for WHOLE BLOOD

A

1-10 C

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31
Q

Heparin for WHOLE BLOOD

A

2 days

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32
Q

RBC contains ___, which transports oxygen from tissues and the bloodstream

A

Hemoglobin

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33
Q

Transfusing __ unit of RBCs usually increases the hemoglobin by ___ g/dL and increases the hematocrit by ___ %

A

1 unit
1 g/dL
35 %

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34
Q

Storage of RBC

A

1-6 Deg C

35
Q

Shelf life of RBC

A

Closed (Depends on anticoagulant)
Open (24 Hrs)

36
Q

Is designed to remove leukocyte from whole blood without removing platelets

A

Inline Filters

37
Q

In frozen red blood cells, freezing extends storage up to ___ years from collection when stored at or below ___ deg C

A

10 Years
-65 deg C

38
Q

Freezing can also be accomplished with a lower glycerol concentration if a _____ is used

A

Liquid Nitrogen Freezer

39
Q

Glycerol concentration is approximately ___% and the initial freezing temperature is ___ Deg C

A

20%
-196 Deg C

40
Q

In frozen red blood cells, the maximum temperature of freezing is ____ Deg C for ____ Years

A

-120 Deg C
10 Years

41
Q

What is the process of thawing, and removing the glycerol from Frozen RBCs

A

Deglycerolization

42
Q

The process of glycerolization and deglycerolization involves entering of blood unit, the system is considered ____ and the prduct must be transfused within ____ days if closed system

A

Open System
14 Days

43
Q

In Washed Red Blood Cells, the reaction can be ____, ____, or ____.

A

Allergic
Febrile
Anaphylactic

44
Q

Washing is accomplished with approximately _____ mL of ____% Saline using the ________

A

1000 mL
0.9% SALINE
Automatic blood cell processor

45
Q

In Red Blood Cells Irradiated, Irradiation can be performed with a

A

Gamma Radiator
Linear Accelerators
Ultraviolet A Irradiation
Nonradioisotopes equipment (xray)

46
Q

The required dose of irradiation is _____ cGy or ____ Gy, the lowest dose should be _____ cGy

A

2500 cGy or 25 Gy
1500 cGy

47
Q

The expiration date of irradiated RBCs is changed to ____ days after irradiation if the available shelf life exceeds ___ days

A

28 days
28 days

48
Q

Transfused platelets normally circulate with a lifespan of ____ days

A

3-4 days

49
Q

Platelet concentrates should contain at least _____ platelets per unit, and under optimal conditions, it should elevate the platelet count by about ____%L in a recipient weighing ____kg

A

5.5x1010
5000%L
75 kg

50
Q

In pooled platelets, the approximate dose is ____ unit per ___ of body weight

A

1 unit per 10/kg of patient body weight

51
Q

The pooled platelets should be stored at ____ to ____ deg C

A

20-24 deg C

52
Q

It is an effective method of harvesting therapeutic dose of platelets from one individual donor

A

Apheresis Platelets

53
Q

Plateletpheresis donors may donate as often as ____ a week or ____ ayear with an interval of ____ hours between procedures

A

2x a week
24 times a year
48 hours

54
Q

A unit of platelets prepared by apheresis should contain a minimum of _____ platelets in _____% of the samples units

A

3x1011 platelets
90%

55
Q

FFP (Fresh Frozen Plasma) contains all coagulation factor including ____, _____ which do not store well at temperatures greater than _____ deg C

A

Labile factors V
VIII
-18 deg C

56
Q

Units of FFP and PF24 are thawed before administration in a ______ to _____ deg C waterbath for approximately _____ to ____ minutes

A

30-37 deg C
30-45 minutes

57
Q

Standard microwave ovens should never be used because they denature ______

A

Plasma Proteins

58
Q

FFP (Fresh Frozen Plasma) is stored at ____ to ____ deg C and should be transfused within ____ hours from thawing

A

1-6 deg C
24 hours

59
Q

In FFP, if not transfused within 24 hours, the product should be relabeled as ______ and stored at ____ to ____ deg C for up to ____ days after thawing

A

“Thawed Plasma”
1-6 deg C
5 days

60
Q

Storage for FFP

A

-18 deg C or colder

61
Q

Shelf life for FFP

A

1 year/12 months

62
Q

What is the cold insoluble precipitate that forms when a unit of FFP is thawed between 1 deg c and 6 deg C

A

Cryoprecipitated AHF (ANTIHEMOPHILIC FACTOR)

63
Q

Factors in cryoprecipitated AHF

A

Von Willebrand Factor
Fibrinogen (Factor 1)
Factor VII
Fibronectin
Factor X11

64
Q

Storage for Cryoprecipitated AHF

A

-18 deg C or colder

65
Q

Shelf life for Cryoprecipitated AHF

A

1 year / 12 months

66
Q

The primary clinical uses of CRYO are as a supplement for patients with deficiencies of ____ and _____

A

Factor XIII and Fibrinogen (Factor I)

67
Q

In Plasma Cryoprecipitated Reduced, the product is relabeled as ______ and is stored at ____ deg C or lower for ___ year from the date of collection

A

Plasma Cryoprecipitated Reduced
-18deg C
1 year

68
Q

The CRYO Poor plasma (CPP) is used primarily in the treatment of ________ because it contains ______

A

Thrombotic Thrombocytopenic Purpura (TTP)
ADAMTS 13

69
Q

In cryoprecipitated antihemophilic factor (pooled), the frozen units first must be thawed in a ____ to ____ water bath for up to ____ minutes using ____ to prevent contamination of the ports

A

30-37 deg C
15 minutes
over wraps

70
Q

In apheresis granulocytes, the number of granulocytes in each product equals or is greater than ______

A

1.0x1010

71
Q

Granulocytes deteriorate rapidly on storage and should be administered within ___ hours of collection.

A

24 hours

72
Q

Storage for Apheresis Granulocyte

A

20-24 deg C without agitation

73
Q

Shelf life for Apheresis Granulocyte

A

24 Hours

74
Q

Shelf life for Modified Whole Blood

A

21 days at 1-6 deg C

75
Q

Transfused platelets normally circulatewith a lifespan of how many days?

A

3-4 days

76
Q

PLATELETS LEUOKOCYTES REDUCED

Platelets collected by apheresis must have less than ____ leukocytes in ____% of the units tested

A

5 x 106
95%

77
Q

The primary clinical use of CRYO are as a supplement for patients with deficiencies of factor ___ and ___

A

Factor XII
Factor I

78
Q

What is the protein that is reduced in Thrombotic Thrombocytopenic Purpura?

A

ADAMTS 13

79
Q

Pooled CEYO must be administered within ___ hours of first entry and should be stored at ___ until transfusion?

A

4 hours
Room Temperature

80
Q

STORAGE for Apheresis Granulocyte

A

20-24 C with agitation

81
Q

STORAGE for fresh frozen plasma

A

-18 or -65C

82
Q

STORAGE for Thawed Plasma

A

1-6 C

83
Q

Storage for Apheresis FFP

A

-18C

84
Q

STORAGE for cryoprecipitated AHF (After Thawing)

A

20-24 C

85
Q

For cancer patients(chemotheraphy) and recipients of hematopoietic progenitor transplants

A

Platelets

86
Q
A

ANGELO FLASHCARDS (3 decks)

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