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Pathology > Blood Coagulation > Flashcards

Blood Coagulation Flashcards

1
Q

Binds to thrombin and converts from a procoagulant to an anticoagulant by activating protein C

A

Thrombomodulin

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2
Q

Triad of Thrombotic Thrombocytopenic purpura

A
  • Microangiopathic hemolytic anemia
  • thrombocytopenia
  • neurological disorders
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3
Q

Idiopathic Thrombocytopenic purpura is what type of hypersensitivity disorder?

A

Type II - due to virus, there is alteration in antigen of platelet which is attacked by AB

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4
Q

An increase in circulating platelet

A

Thrombocytosis

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5
Q

Iron deficiency anemia with chronic blood loss will result in..

A

Secondary Thrombocytosis

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6
Q

A disease where there is a decrease in vWF receptor?

A

Bernard-Soulier Disease

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7
Q

A disorder of platelet-platelet interaction because of a decrease in surface glycoproteins IIb and IIa

A

Glanzmann’s Thrombasthenia

G = glycoprotein

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8
Q

Normal platelet count

A

150k-400k/mm^3

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9
Q

What pathway is triggered by damage to endothelial lining of blood vessel?

A

Intrinsic Pathway

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10
Q

What pathway is triggered by the release of tissue thromboplastin (Factor III)?

A

Extrinsic Pathway

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11
Q

What test is abnormal in Classic Hemophilia?

A

aPTT is abnormal

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12
Q

Factor found both in extrinsic and intrinsic pathway?

A

Factor X (Stuart Factor)

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13
Q

Factors synthesized in the Liver?

A

Factor I, II, V, VI

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14
Q

Which factor is/are increased at birth?

A

Factor VIII (vWF factor)

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15
Q

Which factor is/are acute phase reactants?

A

Factor I (fibrinogen) and Factor VIII: Ag (vWF factor)

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16
Q

Assess Factor XIII (Fibrin stabilizing factor)

A

5M Urea clot dissolution time

17
Q

Monitor extrinsic pathway and anticoagulant therapy with coumadin?

A

Prothrombin Time

18
Q

Measures level of plasminogen activator?

A

Clot Lysis Test

19
Q

Inhibit Vitamin K utilization by Liver cells?

A

Coumarin

20
Q

Binds to Anti-thrombin III to increase anticoagulant effect?

A

Heparin

21
Q

Monitors intrinsic pathway and heparin therapy?

A

aPTT

22
Q

Release of tissue thromboplastin (factor III) into blood stream

A

Disseminated intravascular coagulopathy (DIC)

Pathology (4 decks)

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