Blood Clotting Factors Flashcards
1
Q
What is fibrinogen?
A
- origin: a protein synthesized in the liver
- function: precursor of fibrin
2
Q
What is prothrombin?
A
- origin: a protein synthesized in the liver; synthesis requires vitamin K
- function: precursor of thrombin, which coverts fibrinogen to fibrin
3
Q
What are calcium ions?
A
- origin: an inorganic ion present in plasma
- function: necessary for reactions in all stages of process
4
Q
What is proaccelerin?
A
- origin: a protein synthesized in liver
- function: required for extrinsic & intrinsic mechanisms
5
Q
What is serum prothrombin conversion accelerator ?
A
- origin: a substance synthesized in liver; requires vitamin K
- function: necessary for extrinsic mechanism
6
Q
What is antihemophiliac factor?
A
- origin: globulin synthesized in liver & other tissues
- function: necessary for intrinsic mechanism
7
Q
What is plasma thromboplastin component?
A
- origin: protein synthesized in liver; synthesis requires vitamin K
- function: necessary for intrinsic mechanism
- also known as the Christmas factor
8
Q
What is the Stuart-power factor?
A
- origin: substance synthesized in liver; synthesis requires vitamin k
- function: necessary for extrinsic & intrinsic mechanisms
9
Q
What is plasma thromboplastin antecedent ?
A
- origin: protein synthesized in liver
- function: necessary for intrinsic mechanism
10
Q
What is hageman factor?
A
- origin: source is unknown; proteolytic enzyme
- function: necessary for intrinsic mechanism & to activate plasmin
11
Q
What is fibrin stabilizing factor?
A
- origin: source unknown
- function: renders fibrin insoluble
12
Q
What is platelet accelerator?
A
- origin: a protein synthesized in liver
- function: accelerates action of platelets
13
Q
What is thrombin accelerator?
A
- origin: platelets: phospholipids
- function: accelerates thrombin formation
14
Q
What is platelet thromboplastin factor?
A
- origin: platelets; phospholipid
- function: necessary for intrinsic mechanism
15
Q
What is platelet factor 4?
A
- origin: platelets
- function: binds heparin during clotting