Blood Clotting Factors Flashcards

1
Q

What is fibrinogen?

A
  • origin: a protein synthesized in the liver
  • function: precursor of fibrin
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2
Q

What is prothrombin?

A
  • origin: a protein synthesized in the liver; synthesis requires vitamin K
  • function: precursor of thrombin, which coverts fibrinogen to fibrin
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3
Q

What are calcium ions?

A
  • origin: an inorganic ion present in plasma
  • function: necessary for reactions in all stages of process
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4
Q

What is proaccelerin?

A
  • origin: a protein synthesized in liver
  • function: required for extrinsic & intrinsic mechanisms
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5
Q

What is serum prothrombin conversion accelerator ?

A
  • origin: a substance synthesized in liver; requires vitamin K
  • function: necessary for extrinsic mechanism
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6
Q

What is antihemophiliac factor?

A
  • origin: globulin synthesized in liver & other tissues
  • function: necessary for intrinsic mechanism
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7
Q

What is plasma thromboplastin component?

A
  • origin: protein synthesized in liver; synthesis requires vitamin K
  • function: necessary for intrinsic mechanism
  • also known as the Christmas factor
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8
Q

What is the Stuart-power factor?

A
  • origin: substance synthesized in liver; synthesis requires vitamin k
  • function: necessary for extrinsic & intrinsic mechanisms
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9
Q

What is plasma thromboplastin antecedent ?

A
  • origin: protein synthesized in liver
  • function: necessary for intrinsic mechanism
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10
Q

What is hageman factor?

A
  • origin: source is unknown; proteolytic enzyme
  • function: necessary for intrinsic mechanism & to activate plasmin
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11
Q

What is fibrin stabilizing factor?

A
  • origin: source unknown
  • function: renders fibrin insoluble
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12
Q

What is platelet accelerator?

A
  • origin: a protein synthesized in liver
  • function: accelerates action of platelets
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13
Q

What is thrombin accelerator?

A
  • origin: platelets: phospholipids
  • function: accelerates thrombin formation
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14
Q

What is platelet thromboplastin factor?

A
  • origin: platelets; phospholipid
  • function: necessary for intrinsic mechanism
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15
Q

What is platelet factor 4?

A
  • origin: platelets
  • function: binds heparin during clotting
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