Blood clotting and Inflammation

Question 1

What is Leukotriene B4?

Answer 1

• Neutrophil chemotactic agent
• Abundant during an acute inflammatory process
• Activate sneutrophils, involved in inflammation pain, & in increased IL production
• In pus along with neutrophils

Question 2

What is Prostglandin I2?

Answer 2

• Inhibits platelet aggregation, relaxation of smooth muscle, vasodilateion
• Produced via the cyclooxygenase pathway

Question 3

What is Thromnoxane A2?

Answer 3

• Potent inducer of platelet aggregation and vasoconstriction
• Role in pathogeneis of thrombotic and atherosclerotic disorders

Question 4

What is VEGF?

Answer 4

• Vascualr endothelial growth factor

- Stimulates new BVs formation by binding to endothelial cells that line BVs

Question 5

What is the Von Willebrand factor (VWF)?

Answer 5

• Made by cells lining the walls of veins and arteries
• VWF binds platelet glycoprotein-1-b and facilitates platelet adhesion at the site of injury
• Also a carrier of factor VII

Question 6

What is the role of the β1/β2/a1 receptors?

Answer 6

• α1-R: vasoconstriction & increased BP. In BVs
• β1-R: inotropy (increase contractillity) and chonotropy (increase heart rate). In the heart.
• β2-R: vasodilation, bronchodilation. In BVs & respiratory tract. Target of ASTHMAmeds.

Question 7

What is the role of histamine1/histamine2 receptors?

Answer 7

• Histamine 1R: activation cause seasonal allergies, eczema, pruritus, & increased mucus production
• Histamine 2R: activation leads to increased gastric acid production. In the stomach.

Question 8

What is Leukotriene C4?

Answer 8

• Bronchoconstrictors

- Contribute to asthma

Question 9

What is COX?

Answer 9

-Cyclooxigenase is the enzyme that catalyzes the formation of prostaglandins, thromboxanes, prostacyclins