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Biochem > Blood clotting > Flashcards

Blood clotting Flashcards

1
Q

Factor I

A

fibrinogen (fibrin)

common pathway

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2
Q

Factor II

A

prothrombin (thrombin)
serine protease
contains Gla
all pathways

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3
Q

Gla

A

gamma-carboxylate, calcium chelator

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4
Q

Factor III

A

tissue factor (TF)/thromboplastin
accessory protein
extrinsic pathway

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5
Q

Factor IV

A

calcium

all pathways

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6
Q

Factor V

A

proaccelerin
accessory protein
common pathway

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7
Q

Factor VII

A

proconvertin
serine protease
contains Gla
extrinsic pathway

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8
Q

Factor VIII

A

antihemophilic factor
accessory protein
intrinsic pathway

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9
Q

Factor IX

A

Christmas factor
serine protease
contains Gla
intrinsic pathway

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10
Q

Factor X

A

Stuart factor
serine protease
contains Gla
all pathways, initiates common pathway

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11
Q

Factor XI

A

plasma thromboplastin antecedent
serine protease
intrinsic pathway

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12
Q

Factor XII

A

Hageman Factor
serine protease
intrinsic pathway

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13
Q

Factor XIII

A

fibrin stabilizing factor
converts clots from soft to hard
create fibrin cross-links between Lys and Gln residues

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14
Q

serine protease factors

A

II, VII, IX, X, XI, XII

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15
Q

Gla-containing factors

A

II, VII, IX, X

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16
Q

accessory protein factors

A

III, V, VIII

17
Q

factors activated by thrombin (IIa)

A

I, V, VII, VIII, XI, XIII

18
Q

plasmin

A

serine protease
generated from plasminogen
incorporated into clots along with fibrin and TPA
protected from inhibitors along with TPA until clot dissolves

19
Q

antithrombin (ATIII)

A

serpin (serine protease inhibitor)
inactivates thrombin
affinity for thrombin enhanced when bound to the anticoagulant heparin

20
Q

protein C-protein S complex

A

protein C binds to thrombin, decreases thrombin affinity for fibrinogen
thrombomodulin upregulates thrombin affinity for protein C, making thrombin a protein of anticoagulation

protein C+protein S=APC
APC cleaves factors V and VIII

21
Q

von Willebrand factor (VWF)

A

mediates platelet-collagen binding
binds to and stabilizes factor VIII in blood
allows for platelet adhesion

22
Q

deficiency of factor XII

A

no bleeding disorder!

23
Q

Hemophilia A

A

classic hemophilia

deficiency in factor VIII

24
Q

Hemophilia B

A

Christmas disease

deficiency in factor IX

25
Q

Hemophilia C

A

deficiency in factor XI

26
Q

von Willebrand disease

A

most common coagulopathy
deficiency in VWF
heavier and prolonged bleeding, mild to severe
(inability to bind to factor VIII)

Biochem (6 decks)

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