Blood cells and their immunological & clinical significance - 1 Flashcards

1
Q

blood components

A
  • erythrocytes
  • leukocytes - phagocytes + lymphocytes
  • thrombocytes
  • plasma - non cellular
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2
Q

erythrocytes function

A

contain Hb which carries O2 from lungs to tissues

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3
Q

leukocytes functions

A
  • phagocytes - first line of defence by ingesting pathogens
  • lymphocytes - secrete antibodies and mediate cellular immunity
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4
Q

thrombocytes function

A

prevent bleeding by aiding in clotting

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5
Q

plasma functions

A
  • transport of cellular components of blood
  • transport of nutrients, hormones, proteins
  • removal of waste products e.g. urea, lactic acid
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6
Q

blood investigations include :

A
  • analysis of blood cells - look at cell numbers + proportions
  • blood smears - shape & appearance
  • analysis of plasma components
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7
Q

diagnostic ( what is it & what does it entail? )

A
  • diagnosing a medical condition
  • evaluating the health of an organ
  • identifying certain genetic conditions
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8
Q

clinical ( what is it & what does it entail? )

A
  • initiating right course of treatment
  • choosing health care plan + management
  • monitoring progress
  • prognosis
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9
Q

Analysis of blood cells

analysis of RBC

A
  • to find Hb concentration in blood
  • to find RBC count
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10
Q

Analysis of blood cells

analysis of WBC

A
  • to find total WBC count
  • to measure % of each WBC or differential count
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11
Q

Analysis of blood cells

analysis of platelets

A
  • to find platelet numbers
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12
Q

importance of RBC smears

A
  • investigation of abnormally shapped RBC
  • e.g. sickle cell, cellular parasites
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13
Q

importance of WBC smears

A
  • investigation into WBC types + numbers
  • e.g. abnormal lymphoblasts in acute lymphoblastic leukaemia
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14
Q

importance of platelet smears

A
  • investigation of size, shape, numbers
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15
Q

Full blood count (FBC)

A
  • overall count of blood cells
  • provides differential count
  • measures size of blood cells
  • measures Hb content in RBC
  • used to evaluate health
  • screening for blood disorders
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16
Q

typical FBC parameters include :

A
17
Q

Abnormal RBC values

what does low RBC count or low haematocrit indicate? and causes?

A
  • indication : anaemia
  • causes : bone marrow failure, blood loss, hypervolemia
18
Q

Abnormal RBC values

what does high RBC count or high haematocrit indicate? and causes?

A
  • indication : polycythaemia
  • causes : heart failure - hypoxemia
19
Q

Abnormal MCV

what does high MCV indicate? and causes?

A
  • indication : macrocytosis
  • causes : vitamin deficiency, alcoholism
20
Q

Abnormal MCV

what does low MCV indicate? and causes?

A
  • indication : microcytosis
  • causes : iron deficiency, bone marrow disorders
21
Q

causes of low WBC count or leukopenia

A

viral infections, bone marrow disorders

22
Q

high WBC count or leukocytosis

A

inflammatory diseae(arthritis), infectious disease

23
Q

what does low platelet counts or thrombocytopenia indicate? and causes?

A
  • indication : easy bruising and bleeding
  • causes : leukaemia, chronic infections, HIV
24
Q

what does high platelet count or thrombocytosis indicate? and causes?

A
  • indication : enhances blood clot formation
  • causes : acute infections