Antibodies 1 Flashcards

1
Q

function of immune system

A

protection against disease processes

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2
Q

immune sytem divided into

A

innate + adaptive

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3
Q

characteristics of adaptive system

A
  • can specifically recognise foreign body
  • ability to remember foreign body
  • adapts its response to deal with new invaders
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4
Q

sub-divisions of adaptive system

A
  • cellular - T lymphocytes
  • humoral - B lymphocytes
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5
Q

T cells function + types

A
  • mediate cellular immune response
  • T helper
  • T cytotoxic
  • T regulatory
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6
Q

B cells function

A

mediate humoral immune system by producing antibodies

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7
Q

specificity of antigen recognition is achieved through…

A

antigen-binding receptors on surface of B & T cells

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8
Q

antigen binding receptors of T cells

A

T cell receptor

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9
Q

antigen binding receptors of B cells

A

immunoglobulin receptor cells

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10
Q

functions of antigen binding receptors

A
  • recognise all pathogenic antigens
  • initiate production of specific responses
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11
Q

where does antigen recognition occur?

A

secondary lymphoid organs

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12
Q

1 lymphocyte =

A

1 specificity

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13
Q

how does B lymphocytes produce antibody?

A
  • binds to only 1 antigen + becomes activated
  • activated B cell differentiates
  • produces antibodies with same specificity
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14
Q

antibodies are Igs…

A
  • secreted into circulation by B cells which binds antigen
  • soluble, secreted Igs which are free floating in plasma
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15
Q

membrane-bound Igs

A
  • antigen binding receptors on B cells surface
  • not free floating in plasma
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16
Q

antibody basic structure

A
  • polypeptide chains joined to form a Y shaped molecule
  • 2 identical antigen binding sites
  • flexible “hinge” region
17
Q

what does flexible hinge region allow for?

A

wide range of distances between antigen binding sites

18
Q

structural units of antibody

A
  • 4 polypeptide chains
  • 2 identical heavy “H” chains
  • 2 identical light “L” chains
  • held together by disulphide bonds
19
Q

V & C regions

A
  • V region - antibodies different parts of structure - variable
  • C region - similar parts of antibody - constant
20
Q

V & C regions of light and heavy chains

A
  • light chains : half variable + half constant
  • heavy chains : 1/4 variable + 3/4 constant
  • variable regions from make up antigen binding sites
21
Q

antibody: DOMAINS

A
  • H&L chains fold into globular regions called domains
  • each chain made of structural domain
  • that fold into globular regions held by disulphide bonds
  • L chains have 2 ; H chains have 4
  • these form C&V regions
22
Q

antibody : Fragments

A
  • Igs cleaved at H region
  • generates fragments - Fab + FC
  • Fab - V + C regions ; binds antigen
  • FC - C regions ; binds FC receptors on immune cells
23
Q

antibody : classes

A

antibodies exhibit different versions of C region on H chains

24
Q

five classes of antibodies

A
  • IgG - gamma
  • IgM - mu
  • IgD - delta
  • IgA - alpha
  • IgE - epsilon
25
Q

antibody : subclasses

A
  • IgG - 4 subclasses
  • IgA - 2 subclasses
26
Q

antibody subclasses refelcts…

A

small differences in aa sequences on the C region of H chains

27
Q

antibody : allotype

A

reflects aa sequence variations of C region on H chain within subclasses

28
Q

antiobody : idiotype

A
  • reflects aa sequence variation of the variable region
  • reflect sequence variatiion in the antigen binding specificity
29
Q

antibody : type

A
  • variations of C region in L chain
  • 2 types - kappa + lambda
30
Q

Structure of IgM

A
  • pentamer of basic sub unit
  • extra C domain on H chain
31
Q

structure of IgG

A
  • monomer of basic sub-unit
  • differing slightly in structure of H chain C region
32
Q

structure of IgA

A
  • different structures in serum & mucosal secretions
  • serum - monomer
  • secretory - dimer
  • dimer form - one J chain binds two monomers
33
Q

secretory IgA - secretory piece

A
  • has additional polypeptide chain called secretory piece
  • added during process of transport into external secretions
  • protects molecule from proteases in mucosal secretions
  • facilitates its transport across mucosa
34
Q

structure of IgD

A
  • monomer f basic sub-unit
  • looks like IgG
35
Q

structure of IgE

A
  • extra C domain on H chain
  • monomer of basic sub-unit