Blood bank Flashcards
branch of immunology
use of immunologic principles to study and identify the different blood groups.
Immunohematology
collects blood products from donors
preparation and storing whole blood and blood components
for transfusion.
Blood bank
he received blood by drinking blood from three young boys.
Pope Innocent VII (1492)
He performed the first animal-to-human transfusion by
bloodletting a 16-year-old boy. He exchanged___ of boy’s blood to ___ of lamb’s blood.
Jean Baptiste Denis (1667)
3 ounces - 9 ounces
who received a calf’s blood and suffered from a transfusion reaction but survived and became well.
Anton Mauroy
He transfused sheep’s blood to a student.
Richard Lower
Performed the first human-to-human transfusion in 1795 but this was not documented.
Philip Syng Physick
performed and published a set of animal
experiments which proved that the donor and the recipient must be of the same species.
John Henry Leacock
successfully transfused a woman dying from postpartum hemorrhage with by transfusing blood from the woman’s husband.
James Blundell 1825
Observed red cell lysis in the blood of a woman who died after
receiving a transfusion of sheep blood. He also observed that
incompatible transfusion reactions were associated with hemorrhage and congestion of the kidneys, lungs, and liver.
Emil Ponfick
Observed that human red cells would lyse when mixed with the sera of other animals. He set the stage for the study of the immunologic basis of blood incompatibility.
Leonard Landois
discovered the ABO blood group in __
Karl Landsteiner,1901
and explained the serious reactions that occur in humans as a result of incompatible transfusions
Karl Landsteiner; ABO blood group
clumping of cells.
Agglutination
C was later to be re-named O for the German word ___, meaning ___).
“Ohne” “without”
C was later to be re-named O for the German word ___, meaning ___).
“Ohne” “without”
discovered the fourth less frequent blood group “AB”.
Alfred von Descatello and Adriano Sturli, 1902
discovery of Rh blood group by
Karl Landsteiner and Alex Weiner 1940
The units of heredity; Often defined at the molecular level as a DNA sequence and are responsible for expression of a trait
Genes
One of two or more alternate forms of a gene
Allele
The set of genes possessed by an individual organism
Genotype
A physical trait whose expression depends on the inherited genes along with environmental factors
Phenotype
Also known as forward or cell typing which determines what
antigens are present on the surface of the patient’s red blood
cells. The specimen to be used here is whole blood and
reagents are commercially prepared ANTISERA.
DIRECT TYPING: MOST ROUTINE
Also known as indirect or serum typing which determines what antibodies are present in the plasma or serum of the patient’s sample. This method utilizes RED CELL SUSPENSION (RCS) as the reagent.
REVERSE TYPING
